| WARF: P06053US |  |
| A New Phosphate Binder for Blocking Phosphate Absorption and Reducing Hyperphosphatemia |
| INVENTORS | • | Hector DeLuca, Katarzyna Barycka, Katie Williams |
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing methods and compositions for controlling serum phosphate levels in mammals.
OVERVIEW
The kidney filters toxins and excess nutrients from the blood. It also synthesizes the active form of vitamin D3. In patients with chronic kidney disease, levels of active vitamin D3 decline, leading to hypocalcemia. At the same time, nutrients, particularly phosphorous, accumulate in the blood. Hypocalcemia and excess phosphorous stimulate the secretion of parathyroid hormone (PTH). PTH can cause excess bone resorption, leading to a condition known as renal osteodystrophy. To prevent renal osteodystrophy, patients who are undergoing dialysis are given vitamin D analogs, such as Zemplar®. These analogs suppress PTH levels but are still capable of stimulating intestinal calcium and phosphate absorption. Oral phosphate binders can be given with meals to reduce the absorption of phosphorous, but current binders are expensive or associated with toxic side effects. New methods of reducing phosphate absorption are needed.
THE INVENTION
UW-Madison researchers have developed compositions that reduce phosphate absorption in the intestine. These compositions could be administered to patients to lower blood phosphate levels, decreasing the risk of developing renal osteodystrophy. The compositions consist of dendrimers, which are highly branched, symmetric molecules. Dendrimers are well known therapeutic tools, although dendrimers that bind phosphate were not known previously. The dendrimer compositions of this invention may include a hydrochloride, hydrobromide, hydroacetate or other hydroanionic form.
APPLICATIONS
- Can be administered to patients on dialysis and others who are unable to excrete phosphate to lower their risk of developing renal osteodystrophy
KEY BENEFITS
- Capable of preventing the absorption of more than 50 percent of the phosphate in a patient’s GI tract
- More versatile, cheaper and effective on a weight basis than the most commonly used phosphate binder
- Dendrimer composition is soluble.
STAGE OF DEVELOPMENT
These compositions successfully decreased serum phosphate levels in rats.
ADDITIONAL INFORMATION
For More Information About the Inventors
Intellectual Property Status
Tech Fields
Pharmaceuticals & Vitamin D - Metabolic disorders
CONTACT INFORMATION
For current licensing status, please contact our team at
licensing@warf.org
or phone 608.262.4924. (Clicking this link will open a contact form in a popup window. If you have problems viewing the form, try disabling your popup blocker software.)
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Since its founding as the patenting and licensing arm of the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.
The University of Wisconsin and WARF -
A Single Location to Accelerate Translational Development of New Drugs
The UW-Madison has the integrative capabilities to complete many key components of the drug development cycle, from discovery through clinical trials. As one of the top research universities in the world, and one of the two best-funded universities in the country, UW-Madison offers state-of-the-art facilities unmatched by most public universities.
These include the Small Molecule Screening Facility at the UW Comprehensive Cancer Center; the Zeeh Pharmaceutical Experiment Station, which provides consulting and laboratory services for developing formulations and studying solubility, stability and more; the Waisman Clinical Biomanufacturing Facility; the Wisconsin Institute for Medical Research, which provides UW-Madison with a complete translational research facility; and soon, the Wisconsin Institutes for Discovery, made up of innovative private and public interdisciplinary biomedical research institutes. The highly qualified experts at these facilities are ready to work with you to create a library of candidates for drug development.
Since its founding as the patenting and licensing arm of the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.
The University of Wisconsin and WARF -
A Single Location to Accelerate Translational Development of New Drugs
The UW-Madison has the integrative capabilities to complete many key components of the drug development cycle, from discovery through clinical trials. As one of the top research universities in the world, and one of the two best-funded universities in the country, UW-Madison offers state-of-the-art facilities unmatched by most public universities.
These include the Small Molecule Screening Facility at the UW Comprehensive Cancer Center; the Zeeh Pharmaceutical Experiment Station, which provides consulting and laboratory services for developing formulations and studying solubility, stability and more; the Waisman Clinical Biomanufacturing Facility; the Wisconsin Institute for Medical Research, which provides UW-Madison with a complete translational research facility; and soon, the Wisconsin Institutes for Discovery, made up of innovative private and public interdisciplinary biomedical research institutes. The highly qualified experts at these facilities are ready to work with you to create a library of candidates for drug development.
