| WARF: P04337US |  |
| Microwave-based Breast Cancer Detection Using Hypothesis Testing |
| INVENTORS | • | Shakti Davis, Susan Hagness, Barry Van Veen |
OVERVIEW
X-ray mammography is currently the most effective method
for detecting early-stage breast cancer; however, mammography suffers from
relatively high false positive and false negative rates, requires painful breast
compression, and exposes the patient to low levels of ionizing radiation.
This invention provides a method of identifying malignant breast tissue, which
uses hypothesis testing and microwave backscatter measurements. Breast
tissue is illuminated with an ultrawideband (UWB) microwave pulse. The resulting
backscatter contains contributions from possible tumors, clutter due to the
heterogeneous properties of normal breast tissue, and noise. At multiple
locations throughout the breast, a hypothesis test is performed to determine if
a tumor is present at that location. Under the tumor absent (null) hypothesis,
the measured backscatter data is assumed to consist of clutter plus noise. Under
the alternative hypothesis, the measured data is assumed to consist of
backscatter from a tumor at that location plus clutter and noise. A test
statistic is computed for each location in the breast and compared to a
threshold to determine which hypothesis is most likely given the measured data.
The resulting information indicates the location of detected tumors in the
breast. This approach offers improved patient comfort and safety compared to
X-ray mammography and reduced cost compared to MRI. Furthermore, it may offer
improved accuracy over conventional X-ray mammography.
KEY BENEFITS
- Regular annual screenings using this approach should be more accepted by the public due to the safety of the imaging technique, the comfort of the procedure (no breast compression), the ease of use, and the low cost
- May allow reliable detection of extremely small (millimeter-sized) malignant tumors, even in dense breast tissue or in tissue near the chest wall
- Uses non-ionizing microwave radiation
- Because low-power microwave exposure is harmless, exams may be done more frequently than with X-ray mammography
- Noninvasive -- does not require injection of contrast agents or breast compression
- Potentially reduces the number of false positives associated with X-ray mammography, thus reducing the number of unnecessary biopsies
- Uses relatively low-cost hardware to reduce the cost of screening
- May discriminate between malignant and benign tumors
- May identify tumor characteristics such as size or shape
- Uses an antenna array and short pulses to focus the backscatter signal in space and time, significantly enhancing the response from malignant tissue while minimizing the clutter that results from heterogeneous breast tissue
- Data is processed to remove artifacts such as those generated by the
skin-breast interface
ADDITIONAL INFORMATION
Related Technologies
Intellectual Property Status
Tech Fields
Medical Imaging & Radiation Therapy - Other diagnostic imaging
CONTACT INFORMATION
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