| WARF: P00032US |  |
| Hematopoietic Differentiation of Human Embryonic Stem Cells |
| INVENTORS | • | James Thomson, Dan Kaufman |
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a method for creating hematopoietic cells from human embryonic stem cells.
OVERVIEW
Hematopoietic cells form blood and immune cells and can potentially be used in the treatment of many diseases. Attempts have been made to differentiate mouse embryonic stem cells (ES cells) into hematopoietic cells, but a method for differentiating human ES cells into hematopoietic cells is needed.
THE INVENTION
UW-Madison researchers have developed a method for creating hematopoietic cells from human embryonic stem cells. To create hematopoietic cells, a human ES cell culture is exposed to mammalian hematopoietic stromal cells. At least some of the resulting cells are CD34+ (a standard marker for hematopoietic cells), or can form hematopoietic cell colony-forming units in methylcellulose culture, indicating that the cells are capable of further differentiation.The hematopoietic cells can potentially be transplanted into a patient along with other MHC-compatible human cells, such as pancreatic islets to treat diabetes. Transplanting hematopoietic cells with other MHC-compatible cells improves the acceptance of the other cells.
APPLICATIONS
- Obtaining a wide variety of hematopoietic cells, including lymphocyte precursors, B cells, T cells and macrophages, among others
- Allows the creation of cell cultures for transplantation, transfusion or other uses
KEY BENEFITS
- Co-transplantation of hematopoietic cells with other tissues should result in fewer immune and autoimmune rejection problems than conventional methods.
ADDITIONAL INFORMATION
For More Information About the Inventors
Intellectual Property Status
Tech Fields
Pluripotent Cells - Differentiation
Drug Discovery - Stem cells
CONTACT INFORMATION
For current licensing status, please contact our team at
licensing@warf.org
or phone 608.262.4924. (Clicking this link will open a contact form in a popup window. If you have problems viewing the form, try disabling your popup blocker software.)
Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.
