| WARF: P01258US |  |
| Differentiation and Purification of Neural Precursors from Human Embryonic Stem Cells |
| INVENTORS | • | Su-Chun Zhang, James Thomson, Ian Duncan |
OVERVIEW
This invention provides a simple and efficient method of
differentiating human embryonic stem cells into neural precursor cells for
pharmaceutical screening and potential transplant therapy. This system
is easily standardized. First, human embryonic stem cells (ES cells) are
aggregated into embryoid bodies. Next, the embryoid bodies are treated with
fibroblast growth factors to induce the cells’ development into a relatively
pure culture of neural precursor cells. The resulting neural precursor cells
have been shown to differentiate into neurons and glia, both in vitro and
after transplantation into neonatal mouse brains.
KEY BENEFITS
- Allows efficient differentiation of human ES cells into transplantable neural precursor cells in a standard culture system
- Can be used to isolate a population of neural precursors
- May lead to novel treatments for nervous system damage, including damage resulting from stroke or spinal cord injuries
- Useful for pharmaceutical and toxicological screening of a compound’s effect on neuronal development and function
ADDITIONAL INFORMATION
Intellectual Property Status
Tech Fields
Drug Discovery - Stem cells
Drug Discovery - Pre-clinical testing
Pluripotent Cells - Differentiation
CONTACT INFORMATION
For current licensing status, please contact our team at
licensing@warf.org
or phone 608.262.4924. (Clicking this link will open a contact form in a popup window. If you have problems viewing the form, try disabling your popup blocker software.)
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