| WARF: P06082US |  |
| Multipotent Lymphohematopoietic Progenitor Cells |
| INVENTORS | • | Igor Slukvin, Maksym Vodyanyk, James Thomson |
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a population of cells that comprise unique, multipotent lymphohematopoietic progenitors.
OVERVIEW
Human embryonic stem (hES) cells have the potential to provide a source of specific cell types for research and ultimately, for therapeutic transplantation into humans.
THE INVENTION
UW-Madison researchers have developed a population of cells derived from hES cells that comprise unique, multipotent lymphohematopoietic progenitors. The cells, which were obtained from co-culture of hES cells with OP9 stromal cells, are CD34 and CD43 positive, but CD45 and lin negative. These cells express gene profiles characteristic of definitive, multipotent hematopoietic progenitors and are capable of differentiating into lymphocytes, myeloid cells, erythroid cells and megakaryocytes. They are no longer capable of differentiating into non-hematopoietic lineages. If the cells are cultured until they express CD45, a cell surface marker found in hematopoietic progenitor cells derived from somatic (adult) stem cells, they lose the ability to produce differentiated cells of B lymphoid lineages.
APPLICATIONS
- Provides a method for generating large numbers of human lymphohematopoietic cells for use in scientific research and for potential use in human therapies
KEY BENEFITS
- Represents the earliest multipotent hematopoietic progenitors generated in hES cell/OP9 co-culture
- Provides a population of cells with the potential to form lymphoid cells and all of the cell types from the hematopoietic lineage
- Unlike hematopoietic progenitors derived from somatic stem cells, these lymphohematopoietic progenitors do not express cell surface marker CD45.
ADDITIONAL INFORMATION
For More Information About the Inventors
Intellectual Property Status
Tech Fields
Pluripotent Cells - Differentiation
Research Tools - Cell lines
Drug Discovery - Stem cells
CONTACT INFORMATION
For current licensing status, please contact our team at
licensing@warf.org
or phone 608.262.4924. (Clicking this link will open a contact form in a popup window. If you have problems viewing the form, try disabling your popup blocker software.)
Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.
