| WARF: P98222US |  |
| Human Embryonic Stem Cells |
| INVENTORS | • | James Thomson |
OVERVIEW
This invention provides a purified preparation of pluripotent human embryonic stem (ES) cells. These cell lines are capable of indefinite proliferation in an undifferentiated state when cultured on a fibroblast feeder layer, and subsequent differentiation to cells derived from all three embryonic germ layers (ectoderm, mesoderm and endoderm), even after prolonged culture. The human ES cell lines are characterized by the following cell surface markers: SSEA-1 (-), SSEA-4 (+), TRA-1-60 (+), TRA-1-81 (+) and alkaline phosphatase (+). Methods for isolating human ES cells are also provided.
KEY BENEFITS
- Capable of prolonged (greater than one year) proliferation in an undifferentiated state
- Can differentiate into any cell, including bone, cartilage, muscle, neural, and hematopoetic cells, derived from the three embryonic germ layers
- Maintain a normal karyotype (e.g. remain euploid) during long-term culture
- Retain ability to form trophoblast and express chorionic gonadotropin
- May be induced to differentiate to specific cell types for tissue transplants to treat diseases such as Parkinson’s (dopanergic neurons), juvenile onset diabetes (pancreatic beta-islet cells) and AIDS (lymphocytes)
ADDITIONAL INFORMATION
Related Technologies
Intellectual Property Status
Tech Fields
Pluripotent Cells - Fundamental technologies
Drug Discovery - Stem cells
CONTACT INFORMATION
For current licensing status, please contact our team at
licensing@warf.org
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