| WARF: P03073US |  |
| Cell Line Stably Expressing KvLQT1 and minK |
| INVENTORS | • | Craig January, Sridharan Rajamani, Corey Anderson |
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing an HEK 293 cell line that stably expresses KvLQT1 and mink.
OVERVIEW
One of the key potassium channels in the heart is formed by the co-assembly of protein products from the KvLQT1 (KCNQ1) and minK (KCNE1) genes, which produce the slowly activating delayed rectifier potassium current (IKs). Abnormalities in either of these genes can cause long QT syndrome, a disorder associated with delayed cardiac repolarization, prolonged electrocardiographic QT intervals, and the development of ventricular arrhythmias and sudden death.
THE INVENTION
UW-Madison researchers have developed an HEK 293 cell line that stably expresses KvLQT1 and minK. Since unintended block of potassium channel activity by drugs can cause an acquired form of long QT syndrome, which leads to potentially fatal arrhythmias, this system provides an important screening tool for drugs in development.
APPLICATIONS
- Testing lead compounds and drugs for their potential to block activity of the KvLQT1-minK cardiac potassium channel
KEY BENEFITS
- The HEK 293 cell line is stable, providing a constant source of material.
- Cells are of human lineage and can be studied at room or body temperature, providing the highest stringency assay.
ADDITIONAL INFORMATION
For More Information About the Inventors
Intellectual Property Status
Assigned to WARF as biological material.
Tech Fields
Research Tools - Cell lines
Drug Discovery - Pre-clinical testing
CONTACT INFORMATION
For current licensing status, please contact our team at
licensing@warf.org
or phone 608.262.4924. (Clicking this link will open a contact form in a popup window. If you have problems viewing the form, try disabling your popup blocker software.)
Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.
