| WARF: P95097US |  |
| 26,27-Dimethylene-1 alpha,25-Dihydroxyvitamin D2 and 26,27-Dimethylene-24-Epi-1 alpha,25-Dihydroxyvi |
| INVENTORS | • | Hector DeLuca, Naoshi Nakagawa |
OVERVIEW
Vitamin D2 analogs in which a cyclopentane ring is introduced onto the 25-carbon of the side chain of a 1 alpha,25-dihydroxyvitamin D2 and its 24-epimer. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1 alpha,25-dihydroxyvitamin D3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.
ADDITIONAL INFORMATION
Intellectual Property Status
Tech Fields
Pharmaceuticals & Vitamin D - Musculoskeletal
CONTACT INFORMATION
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