| WARF: P99126US |  |
| Crystalline 1 Alpha-hydroxyvitamin D2 and Method of Purification Thereof |
| INVENTORS | • | Hector DeLuca, Rafal Sicinski, Hazel Holden, James Thoden |
OVERVIEW
A method of purifying 1a-hydroxyvitamin D2 to obtain 1a-hydroxyvitamin D2 in crystalline form. The method includes the steps of boiling a solvent selected from the group consisting of ethyl formate, ethyl acetate and a 2-propanol-hexane mixture under inert atmosphere, dissolving a product containing 1a-hydroxyvitamin D2 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of 1a-hydroxyvitamin D2 crystals, and recovering the 1a-hydroxyvitamin D2 crystals. Optionally, petroleum ether may be added to the solvent after dissolving the product to be purified in the solvent.
ADDITIONAL INFORMATION
Intellectual Property Status
Tech Fields
Pharmaceuticals & Vitamin D - Musculoskeletal
Pharmaceuticals & Vitamin D - Vitamin D
CONTACT INFORMATION
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