| WARF: P92184US |  |
| Synthesis of 19-Nor Vitamin D Compounds |
| INVENTORS | • | Hector DeLuca, Heinrich Schnoes, Kato Perlman, Rolf Swenson |
OVERVIEW
A convergent synthesis of 19-nor-vitamin D compounds, specifically 19-nor-1alpha, 25-dihydroxyvitamin D3, is disclosed. The synthesis can also readily be utilized for preparing other 1alpha-hydroxylated 19-nor-vitamin D compounds. The key step in the synthesis is a suitable application of Lythgoe's procedure i.e. a Horner-Wittig reaction of the lithium anion of a phosphine oxide with a Windaus Grundmann ketone to give, after any necessary deprotection, the desired 19-nor-vitamin D compound.
ADDITIONAL INFORMATION
Intellectual Property Status
Tech Fields
Pharmaceuticals & Vitamin D - Skin & connective tissue
CONTACT INFORMATION
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