| WARF: P02091US |  |
| (20S)-1Alpha-Hydroxy-2-Methylene-19-Nor-Vitamin D3 and its Uses |
| INVENTORS | • | Hector DeLuca, Rafal Sicinski, Pawel Grzywacz |
OVERVIEW
Vitamin D (1,25-dihydroxyvitamin D3) is a highly potent regulator of calcium
homeostasis and plays a role in cellular differentiation. The 19-nor-vitamin D
compounds, a recently discovered class of vitamin D analogs, show a selective
activity profile with high potency in inducing cellular differentiation and very
low calcium mobilizing activity, making them potentially useful for treating
various disorders. This invention provides a new vitamin D analog,
(20S)-1alpha-hydroxy-2-methylene-19-nor-vitamin D3. This compound
exhibits relatively high binding to vitamin D receptors. It also exhibits
greater intestinal calcium transport activity and greater ability to mobilize
calcium from bone than 1,25-dihydroxyvitamin D3, making it very potent and
highly specific in its calcemic activity. This compound also exhibits high cell
differentiation activity.
KEY BENEFITS
- Promising therapeutic agent for diseases where bone formation is desired, such as osteoporosis and osteomalacia
- May be useful for improving bone fracture healing and bone grafts
- Potentially useful as an anti-cancer agent, particularly against leukemia, colon, breast, and prostate cancers
- Especially useful for treating immune disorders including multiple sclerosis, lupus, diabetes mellitus, host-versus-graft reaction, and organ transplant rejection
- Prospective treatment for inflammatory diseases such as rheumatoid arthritis, asthma, and inflammatory bowel diseases
- May be useful for treating skin conditions such as psoriasis, dermatitis, eczema, keratosis, wrinkles, slack skin, dry skin, and insufficient sebum secretion
- Potential treatment for other disorders including acne, alopecia, and hypertension
ADDITIONAL INFORMATION
Intellectual Property Status
Tech Fields
Pharmaceuticals & Vitamin D - Vitamin D
CONTACT INFORMATION
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