| WARF: P95199US |  |
| Method of Synthesizing 9-Cis-Retinoic Acid |
| INVENTORS | • | Hector DeLuca, Praveen Tadikonda |
OVERVIEW
A method of synthesizing 9-cis-retinoic acid, all-trans-retinoic acid or 9-nor-retinoic acid is disclosed. The method comprises the steps of adding a Gringnard reagent of HC=C-C=CH-CH2-OH to 2,2,6 trimethyl cyclohexanone is disclosed. R is a methyl group or H and the CH2-OH group is in either the cis or trans orientation relative to the HC=C- group. The resulting product is converted into retinoic acid. In the preferable form of the present invention, a tritium-labelled retinoic acid is synthesized, wherein the labelling is at the C20 position. A preparation of tritium-labelled 9-cis-retinoic acid with a specific activity of greater than 65 Ci/mmol is also enclosed. In a most preffered embodiment, the specific activity is greater than 75 Ci/mmol.
ADDITIONAL INFORMATION
Intellectual Property Status
Tech Fields
Pharmaceuticals & Vitamin D - Vitamin D
CONTACT INFORMATION
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