| WARF: P98272US |  |
| Use of Vitamin D Compounds to Prevent Transplant Rejection |
| INVENTORS | • | Hector DeLuca, Margherita Cantorna, Colleen Hayes, Debra Hullett, Hans Sollinger, Jean Humpal-Winter |
OVERVIEW
This invention is a method of moderating transplant rejection in a transplant recipient by treating the patient with a vitamin D compound or analog, preferably
1,25(OH)2D3, to allow the acceptance of foreign grafts. The inventors have discovered that the vitamin D derivatives act as selective modulators of the immune response as opposed to causing overall immune suppression. Thus, these derivatives allow appropriate resistance to infection while providing tolerance to transplants that differ in histocompatibility. Additionally, the transplant recipient would not suffer from bone demineralization
KEY BENEFITS
- Analogs of 1,25(OH)2D3 not only prevent bone demineralization but also improve bones of the transplant recipient
- Appropriate for all organ transplants but preferably for heart, liver, kidney, pancreas, lung and intestinal transplants
- Studies in mice have shown that use of the vitamin D compounds can increase transplant survival from 10 to 30% relative to an untreated recipient, without increasing the risk of opportunistic infection or bone loss
ADDITIONAL INFORMATION
Intellectual Property Status
Tech Fields
Pharmaceuticals & Vitamin D - Vitamin D
Pharmaceuticals & Vitamin D - Organ & tissue transplants
CONTACT INFORMATION
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