| WARF: P04019US |  |
| HERG-Specific Antisera |
| INVENTORS | • | Gail Robertson, Barry London, Elon Roti Roti, Samantha Delfosse, Eugenia Jones |
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing polyclonal antibodies against HERG1.
OVERVIEW
The gene HERG1 encodes a potassium-selective ion channel important in maintaining normal cardiac rhythm and cell growth.
THE INVENTION
UW-Madison researchers have developed polyclonal IgG antibodies against 15-amino acid peptide sequences unique to HERG1. The peptide sequences were selected based on their antigenicity, surface probability and conservation among species. These sera have been validated for use in Western blot, immuno-precipitation and histological characterization of native and expressed HERG channels. In validation tests, they strongly outperformed commercially available antibodies in terms of sensitivity, selectivity and versatility for a wide range of uses.
APPLICATIONS
- Determining the expression profile and distribution of HERG isoforms in tissues, cells and cellular components
- Identifying HERG channel composition, subunit stoichiometry and protein/protein interactions
- Determining the surface expression and stability of channels comprised of one or both HERG isoforms
- Studying the role of HERG channels in arrhythmia and cancer
KEY BENEFITS
- More sensitive, selective and versatile than currently available antibodies
ADDITIONAL INFORMATION
For More Information About the Inventors
Intellectual Property Status
Assigned to WARF as biological material.
Tech Fields
Research Tools - Antibodies
CONTACT INFORMATION
For current licensing status, please contact our team at
licensing@warf.org
or phone 608.262.4924. (Clicking this link will open a contact form in a popup window. If you have problems viewing the form, try disabling your popup blocker software.)
Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.
