| WARF: P05253US |  |
| A Polyclonal Antibody Directed Against the C-Terminus of HERG |
| INVENTORS | • | Craig January, Qiuming Gong, Zhengfeng Zhou |
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in a versatile polyclonal anti-HERG antibody.
OVERVIEW
HERG (human ether-a-go-go-related gene) encodes a potassium ion channel important for maintaining normal cardiac rhythm and cell growth.
THE INVENTION
UW-Madison researchers have developed a versatile polyclonal anti-HERG antibody. This antibody was developed in 1997 using a fusion protein that included 181 amino acids from the C-terminus of HERG. It detects HERG 1a and 1b. The antibody’s specificity has been tested by Western blot, immunohistochemical and immunoprecipitation assays, including histological characterization of native and expressed HERG channels. In validation tests, it outperformed commercially available antibodies for a range of uses.
APPLICATIONS
- Analysis of HERG channel proteins
KEY BENEFITS
- More sensitive, selective and versatile than commercially available antibodies
- Reliable – has been used by academic labs worldwide for more than eight years
ADDITIONAL INFORMATION
For More Information About the Inventors
Publications
Zhou Z., Gong Q., Epstein M.L. and January C.T. 1998. HERG Channel Dysfunction in Human Long QT Syndrome: Intracellular Transport and Functional Defects. J. Biol. Chem. 273, 21061-21066.
Intellectual Property Status
Assigned to WARF as biological material.
Tech Fields
Research Tools - Antibodies
CONTACT INFORMATION
For current licensing status, please contact our team at
licensing@warf.org
or phone 608.262.4924. (Clicking this link will open a contact form in a popup window. If you have problems viewing the form, try disabling your popup blocker software.)
Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.
