| WARF: P98022US |  |
| CDNAs and Proteins Involved in Hypoxia and Circadian and Orphan Signal Transduction Pathways |
| INVENTORS | • | Christopher Bradfield, Yi Zhong Gu, John Hogenesch |
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing new and distinct members of the bHLH-PAS superfamily of transcription regulators.
OVERVIEW
The distinguishing characteristic of members of the emerging bHLH-PAS superfamily of regulatory proteins is a 200-300 stretch of amino acids known as the PAS (PER/ARNT/SIM) domain. Many of the proteins also harbor a bHLH (basic helix-loop-helix) motif that plays a primary role in dimer formation. The bHLH motif is also found in a variety of transcription factors that use homotypic interactions to regulate aspects of cell growth and differentiation.
THE INVENTION
UW-Madison researchers have identified eight isolated nucleic acids and proteins that are new and distinct members of the bHLH-PAS superfamily of transcription regulators. These “MOPs” (members of PAS) are useful for a wide variety of research, diagnostic and therapeutic applications. MOPs 1, 2, 5, 6 and 7 are induced by low oxygen and/or may be involved in response to hypoxia. MOPs 3, 4 and 8 may be involved in regulating circadian rhythm. While the MOPs share certain common features among themselves and with other new members of the bHLH-PAS superfamily, each MOP is a distinct and unique member of the family.
APPLICATIONS
- Research tools for elucidating environmentally and developmentally controlled signal transduction pathways
- Diagnostic and therapeutic agents for detection and control of such pathways
KEY BENEFITS
- Nucleic acids may be used as probes to detect the presence or expression of genes encoding MOPS or related genes.
- Nucleic acid molecules may also be used to control the production of various MOPs to regulate the amount of protein available for participation in cellular signaling pathways.
ADDITIONAL INFORMATION
For More Information About the Inventors
Intellectual Property Status
Tech Fields
Research Tools - DNA & RNA tools
CONTACT INFORMATION
For current licensing status, please contact our team at
licensing@warf.org
or phone 608.262.4924. (Clicking this link will open a contact form in a popup window. If you have problems viewing the form, try disabling your popup blocker software.)
Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.
