Technologies

Diagnostic Assays : Personalized medicine

Technologies

Application of NADH Cytochrome B5 Reductase/System for Direct Metabolism of Xenobiotics

UW-Madison researchers have now shown that NADH cytochrome b5 reductase, along with cytochrome b5, can directly metabolize a hydroxylamine drug metabolite that may be important in sulfonamide drug hypersensitivity. Thus, NADH cytochrome b5 reductase and cytochrome b5 play a direct role in drug detoxification. Since many compounds generate hydroxylamine metabolites, including AIDS drugs and some carcinogens, differences in the activity or expression of the NADH cytochrome b5 reductase system may be important in drug toxicity and possibly carcinogenesis.
P02388US