Technologies

Food & Supplements : Nutraceuticals

Food & Supplements Portfolios

Technologies

Preen Oil: The Nutritional Approach to Chronic Inflammation

UW–Madison researchers have developed methods of using preen oil as a food supplement to treat chronic inflammation in human and non-human animals, birds and fish.

Preen oil may be given orally as a pharmaceutical composition, added to human food products or included in animal, bird or fish food. The fatty acids in the oil accumulate in tissues where they inhibit the pro-inflammatory cytokines IL-1 and IL-6 and reduce chronic inflammation, including chronic joint inflammation associated with rheumatoid arthritis and other diseases.
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Tannins Boost Gastrointestinal Immunity

UW–Madison researchers have developed tannin-based formulations to counteract or prevent the gastrointestinal problems associated with parenteral/enteral feeding. The researchers discovered that various types of tannins, including proanthocyanidins and hydrolysable tannins, promote mucosal barrier strength and immunity.

The formulations can take solid or liquid form, and may include other nutrients like sugars, amino acids, lipids and vitamins.
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Preventing and Treating Pregnancy Hypertension with CLA Supplement

UW–Madison researchers have developed a method to treat and prevent PIH, and therefore reduce the risk of preterm birth, using conjugated linoleic acid (CLA) as a health supplement. CLA is an unsaturated fatty acid found mainly in cow’s milk and other animal products. CLA currently is used at high doses to reduce fat and increase lean muscle mass, but lower doses should be therapeutic to PIH without these side effects.

Women diagnosed with PIH or at risk of preeclampsia could take a safe and effective amount of the CLA isomer t10:c12 as a pill, injection, prenatal vitamin, enriched dairy product or other form. This would apply both to women who are pregnant or planning to become pregnant.
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GMP Protein Burns Fat, Boosts Bone Strength in Women

UW–Madison researchers have developed dietary approach to increase bone mineralization and fat metabolism in female humans and animals using GMP. The peptide can be isolated from whey using standard methods and administered in an effective amount as a food product, nutraceutical or dietary supplement.
P110272US03

Making Large Quantities of Health-Promoting Thiosulfinates

UW–Madison researchers have developed a simple and quick way of making large amounts of thiosulfinates and desirable conjugates.  They heated onions to inactive the enzymes, particularly LF synthase.  The precursor sulfoxide compounds in the heated onion, which were not destroyed by this process, were added to a small portion of macerated garlic.  The garlic extracts were washed to remove the native garlic organosulfur compounds, leaving a mixture of garlic enzymes and sulfoxide precursors from onions.  This mixture produces thiosulfinates, rather than LF, from the onion.  The thiosulfinates then can be extracted from the garlic-onion mixture.

This method results in high yields of thiosulfinates with high purity.  Traditional organic synthesis approaches would require chromatography purification and the use of toxic and dangerous chemicals to achieve such high yields and purity.  The thiosulfinate mixture then can be combined with thiols in water to easily yield mixed disulfide conjugates, which are odorless and maintain biological activities of the thiosulfinates.
P09143US02

Conjugated Nonadecadienoic Acid (CNA) Reduces Body Fat and Inhibits LPL Activity

UW-Madison researchers have developed a method of using conjugated nonadecadienoic acid (CNA) to inhibit LPL activity in humans or other animals. CNA is a 19 carbon, free fatty acid with a pair of conjugated double bonds. Its biological effects on the metabolism of body fat are similar to those of CLA.

To inhibit LPL activity, an agent containing CNA and at least one derivative of CNA is administered to an animal. In addition to controlling body fat in animals, CNA also acts to inhibit cyclooxygenase activity and platelet aggregation.
P00277US

Fractionation of Whey Proteins by Complex Formation

UW-Madison researchers have developed an efficient and cost-effective method of separating whey proteins from solutions of whey protein concentrate by complexing them with polysaccharides. The process yields at least a 95 percent pure alpha-lactalbumin fraction and a 90 percent pure beta-lactoglobulin fraction.
P01303US

Use of Lipoxygenase Inhibitors to Control Body Fat

In a study designed to better elucidate the relationship between fat reduction and inhibitors of the AA pathway, such as CLA, a team of researchers has shown that inhibitors of lipoxygenases show potential for controlling body fat in humans and other animals. The investigators tested both an inhibitor of cyclooxygenase and an inhibitor of lipoxygenases in an attempt to examine the AA-related effects of CLA. The cyclooxygenase inhibitor failed to show an effect upon the body composition of mice; however, the lipoxygenase inhibitor produced a shift in body composition as well as physiological changes related to fat metabolism that were very similar to CLA. When both CLA and the lipoxygenase inhibitor were fed to mice, the researchers observed an even greater effect on body composition.
P01168US

Method for Reducing Adverse Effects of a Weight Loss Regimen

UW–Madison researchers have developed a method for using conjugated linoleic acid (CLA) to reduce some of the adverse effects associated with a negative calorie balance. CLA has been associated with numerous beneficial physiological effects, and can help facilitate weight loss by minimizing some of the negative effects linked to a calorie deficit.
P00117US

Unfermented Gel Fraction From Psyllium Seed Husks

UW-Madison researchers have developed a method for isolating and purifying the gel-forming component of psyllium seed husks. This provides the same laxative and cholesterol-lowering effects of intact psyllium seed husks, but in a form that is easily administrable as a tablet, capsule or liquid. The method of fractionating psyllium seed husks relies on chemical isolation and physical separation (centrifugation) of the desired compound.
P99110US

Production of Substantially Pure Kappa Casein Macropeptide

A UW-Madison researcher has developed a whey-adsorbing process that produces a substantially pure cow milk protein, kappa-casein macropeptide (CMP), for nutraceutical purposes. CMP is produced as an effluent. Then, by depleting the product of the aromatic amino acids tyrosine, phenylalanine, and tryptophan through hydrolysis, CMP is freed from its characteristic bitter taste.
P98198US

Enhancing the Body’s Natural Killer Cells with CLA

UW–Madison researchers have developed a method of enhancing natural killer lymphocyte activity and basal levels by preparing CLA in animal feed and veterinary compositions. CLA also may be incorporated in human health supplements.
P98096US

Production of K-Casein Macropeptide for Nutraceutical Uses

A UW-Madison researcher has developed a whey-absorbing process that produces a pure cow milk protein, kappa-casein macropeptide (CMP), for nutraceutical purposes.  This process uses two opposite polarity ion exchangers in a series. The adsorbed product is hydrolyzed and reacted with water, depleting it of the aromatic amino acids tyrosine, phenylalanine and tryptophan, which usually cause its bitter taste.
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