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WARF’s portfolio of more than 1,700 technologies covers a wide range of categories, including analytical instrumentation, pharmaceuticals, food products, agriculture, research tools, medical devices, pluripotent stem cells, clean technology, information technology and semiconductors.
Information summaries, which describe each technology and its applications, benefits, inventors and patent status, can be downloaded, printed and shared by clicking on the technology category links to the left on this page.
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The researchers found that MTDH-SND1 protein interaction is important for the expansion and function of prostate tumors as well as luminal and basal breast tumor initiating cells. Their work provides novel peptides that target this protein complex to help control tumor initiation, recurrence and metastasis by combating tumor initiating cells, with minimal impact on normal tissues.
Synergistic combination offers efficacy with significantly reduced amounts of drug and corresponding toxicity, which could potentially expand the relevant patient population.
The polymers were designed to resemble host-defense peptides (HDPs), which are natural molecules that exhibit antimicrobial activities.
Specifically, a suture is coated with a mineral layer under physiological temperature and pH, resulting in a nano-porous structure with high surface area for protein binding. Then biologically active molecules are bound to the surface of the suture for subsequent release in vivo. Protein binding can be achieved rapidly in the operating room, and the process can be adapted to enable the incorporation of a wide range of other therapeutic molecules, in addition to proteins.
The system is preloaded with medical histories and images from known clinical cases. The trainee is asked to recommend recall instructions. His/her responses are tested against the answers of an expert clinician and pathologic correlation. The program reports any divergence between the two.
The program uses actual clinical data and is designed to provide realistic yet demanding simulation. In addition to recall instructions, a trainee may be asked to complete other tasks, such as locating a suspicious lump or predicting whether a biopsy will be required.