Explore WARF Inventions and Patents

WARF Technologies

WARF’s portfolio of more than 1,600 patented technologies covers a wide range of categories, including analytical instrumentation, pharmaceuticals, food products, agriculture, research tools, medical devices, pluripotent stem cells, clean technology, information technology and semiconductors.

Information summaries, which describe each technology and its applications, benefits, inventors and patent status, can be downloaded, printed and shared by clicking on the technology category links to the left on this page.

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New Inventions

Improved System for Stroke Therapy and Rehabilitation

UW-Madison researchers have developed an improved system for stroke therapy and rehabilitation.  This system collects movement intention signals from the brain in real-time via EEG and initiates functional electrical stimulation (FES) of the appropriate muscle(s) to assist the neurons in regrowing their connections from the brain to the muscles along the correct pathways.  Additional general sensory stimulation may be added to this therapy to further encourage proper neuron regrowth. 

Temperature Gradient Handling System for Surface Plasmon Resonance (SPR) Measurements

Researchers in the Department of Chemistry and Biochemistry at the University of Wisconsin-La Crosse have developed a surface plasmon resonance (SPR) based method for measuring, in a single experiment, the temperature dependence of binding kinetics for biomolecular interactions. The method is based on a novel sample handling system that generates a spatial temperature gradient across an SPR sensor and is label free.

High Accuracy Angle Measuring Device for Industrial, Medical, Scientific or Recreational Use

A UW-Stout researcher has developed a high-accuracy angle measurement system that addresses the problems inherent to commercially available systems. In this novel device, a high accuracy rotary optical encoder is controlled by a microprocessor. The encoder consists of rotating optical disks and sensors that are precisely formed and placed to read angles with 0.001 arc second sensitivity (average) and better than ±0.1 arc second accuracy (single readings), which is comparable to the accuracy of the high-end commercial encoders currently on the market. This accuracy is maintained with strategies that combat the mechanical sources of error that are known disadvantages of other devices. The system can also be adjusted to compensate for any asymmetrical shifts that may occur. Mechanical sources of error and noise are further minimized by precision placement of disks and sensors, as well as low-friction reference points that keep components centered and level during rotation. In addition, multiple sensor heads eliminate major readout errors and remove the need for recalibration. All of these features and benefits are contained within a design that is both compact and portable. Beyond high accuracy and portability, the cost of this new angle measurement system is substantially lower than a high-end commercial system because it is easily constructed from readily available industrial grade components, bringing the production cost to roughly $2,000. Strikingly, this cost is comparable to the advertised price of other rotary position encoders that are less than one tenth as accurate. Its high accuracy, low cost, and portability make this new angle measurement system a strong option for use in virtually any of the current applications for absolute rotary encoders.

“Green” Catalytic Systems for Solvent-Free Alcohol Oxidations

Research from the University of Wisconsin-La Crosse has led to the discovery and development of a novel suite of catalytic systems for industrially-relevant green oxidations including the oxidative conversion of primary and secondary alcohols to value-added aldehydes and ketones. Similar systems have been developed for the oxidation of olefins to produce important epoxides, and for the oxidation of alkanes to produce alcohols. Specifically the team has developed a series of iron-based catalysts known as ‘helmet’ phthalocyaninaoto complexes of iron(III). Preliminary studies have focused on the use of what is commonly referred to as the ‘diiPc’ iron(III) system. Notably, the team has shown that this system is capable of catalytically oxidizing a diverse array of substrates including five non-benzylic alcohols (1-pentanol, 2-pentanol and cyclohexanol as well as 2,4-dimethyl-3-pentanol and 5-hydroxymethylfurfural) in the absence of added organic solvent. The presence of water as the monodentate axial ligand in the diiPc complex allows for markedly increased solubility in non-aromatic alcohols, making it an ideal catalyst for use with a much wider and more diverse range of substrates under solvent free conditions. It is envisaged that modification of the diiPc and related ligands will be undertaken to impart further enhancements to catalyst solubility in substrates or water, and/or superior stability in substrate alcohols. In addition to the diiPc system, the team have also developed a means of forming derivatized catalysts utilizing what is commonly referred to as a “helmet naphthalocyaninato” iron(III) complex. Specifically, a sulfonated version has been produced that possesses excellent solubility in water due to the added hydrophilic groups. To date, the sulfonated helmet naphthalocyaninato complex has been shown to provide for efficient formation of acetone from isopropanol as well as conversion of 2-pentanol to 2-pentanone using hydrogen peroxide as the primary oxidant. As such we anticipate that the same system would also be effective in the oxidation of 2-butanol to produce methyl ethyl ketone (MEK), an important commodity scale industrial chemical, and in many other commercially important transformations. Furthermore, preliminary studies have shown this molecule can be immobilized on various solid supports including anion-exchange resins, thereby resulting in a heterogeneous catalyst that can be utilized in the development of catalytic transformations that occur under flow conditions. Additionally, we now know that the sulfonated catalyst efficiently catalyzes the oxidation of phenol with hydrogen peroxide to produce para-benzoquinone. This transformation, along with other related reactions, is very important in the treatment of wastewater.

Nylon-3 Polymers Active Against Clostridium Difficile

UW–Madison researchers and collaborators at Emory Medical School have developed nylon-3 polymers and copolymers active against C. difficile. The polymers have been shown to inhibit outgrowth/growth of the bacteria in spore and vegetative form.
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New Patents

Use of Peptides of Syndecan-1 to Inhibit Angiogenesis

UW–Madison researchers have developed a method of using a novel peptide from the extracellular domain of syndecan-1 to inhibit angiogenesis. The peptide interferes with the formation of new blood vessels by blocking the activation of αvβ3 and αvβ5 integrins. Recent in vivo mouse data shows that this peptide successfully inhibits angiogenesis and reduces tumor size without adverse side effects.

Energy-Efficient Parallel Processing

A UW–Madison researcher has developed a technique to reduce the clock speed of spinning cores. This conserves energy during fine-grained synchronization events that would otherwise be fatally slowed by multiple system calls.

Specifically, clock dividers are provided on each core, allowing rapid changes in clock frequencies. A spinning core is slowed but still can operate in the environment of the other processors by making certain frequency adjustments. Power fluctuations that may result from abrupt clock speed changes can be minimized by disabling processor functions prior to the change.

Energy-Efficient Multiplier Circuitry for GPUs

UW–Madison researchers have developed a new circuit system for multiplying floating-point numbers. The system combines a traditional floating-point multiplier with a power-of-two multiplier that works by shifting operations. Substantial power savings may be realized by selectively steering some operands to the power-of-two multiplier.

The different circuits have different advantages. The floating-point multiplier uses more power but is more versatile, while the power-of-two multiplier uses less power but is less versatile.
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