Through Technologies

Explore WARF Inventions and Patents

WARF Technologies

WARF’s portfolio of more than 1,600 patented technologies covers a wide range of categories, including analytical instrumentation, pharmaceuticals, food products, agriculture, research tools, medical devices, pluripotent stem cells, clean technology, information technology and semiconductors.

Information summaries, which describe each technology and its applications, benefits, inventors and patent status, can be downloaded, printed and shared by clicking on the technology category links to the left on this page.

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New Inventions

Treating Hemophilia B with Modified Protein

A UW–Madison researcher has developed new Factor IX mutants for treating blood coagulation conditions, including hemophilia B, hemorrhagic disorder and thrombosis. The modified proteins contain combined mutations in the heparin and antithrombin binding sites that prolong half-life and stability.

The new mutants show improved in vivo activity and more sustained therapeutic effect than naturally occurring Factor IX. They could potentially be administered intravenously, orally or by another route.
P150063US02

Treating Iron Overload with Block Copolymers

UW–Madison researchers have developed new block copolymers for forming micelles that can respond to the oxidation state of their environment and chelate iron (II) and (III) ions. At suitable concentrations the copolymers can form micelles to prolong circulation in the blood and bind to non-transferrin bound iron. The micelles then break up in cells in the presence of oxidizing agents such as hydrogen peroxide and are cleared from the body by the liver or kidney route.

The copolymers include a polyhydroxamic acid-containing block and a polyferrocenyl block. They can be prepared by standard peptide synthesis or polymerization methods.
P140395US02

Modified Yeast with Enhanced Tolerance for GVL Biomass Solvent

UW–Madison researchers have developed a genetically modified strain of Saccharomyces cerevisiae that is more resistant to GVL toxicity and grows more than 1.5 times faster than wild yeast in the presence of GVL.

The researchers deleted two genes (Pad1p and Fdc1p) in the yeast that play a role in mediating GVL tolerance. The new strain is the first ethanol-producing yeast specifically tailored for GVL-based techniques.
P140430US02

Combined Capacitor/Inductor with Improved Performance

UW–Madison researchers have now mitigated the problem of parasitic inductance. Their new design features a loop-back terminal structure that minimizes the net magnetic field induced by the capacitor current. In other words, the capacitor leads are routed back up through the middle of the core to cancel the increased inductance seen at the capacitor terminals.
P150389US01

Sustainable Process to Remediate Liquid Waste Streams

UW–Madison researchers have developed an environmentally sound and cost-effective system to remediate effluent streams containing organometallic/inorganometallic contaminants. Metals are recovered in the process and the treated water can be recycled for industrial applications.

The system includes units for electro-oxidation, electro-deposition and electro-adsorption. These units work sequentially to (1) break the strong chemical bonds in the waste stream, (2) recover the heavy metal ions and (3) remediate the organic/inorganic material.

A primary advantage of the new system is the redesigned electro-deposition unit, which houses a concentrating cathode and helps in the recovery of metals present even in very low concentrations in a reusable form.
P140335US02
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New Patents

High Titer Recombinant Influenza Viruses for Vaccines

UW-Madison researchers have developed an improved reassortant virus for use in producing high levels of the H5N1 avian influenza strain, as well as seasonal influenza strains. They discovered that using the NA segment from a “harmless” strain that grows well in eggs resulted in significantly greater amounts of infectious virus in eggs or cell lines. The inventors found that using a different isolate of this strain as a source for the other six viral segments also improves yield.
P06370US

Coatings That Inhibit Crystallization of Amorphous Drugs to Improve Stability

UW-Madison researchers have developed a method of coating amorphous drugs to inhibit surface crystallization and improve their stability.  An ultra thin polyelectrolyte coating or other biocompatible immobilizing material is applied to the surface of an amorphous solid.  This coating allows amorphous pharmaceuticals to maintain their amorphous state, and therefore their solubility, over extended periods of time. 
P07314US

New Amphiphiles for Manipulating Membrane Proteins

UW–Madison researchers have developed improved amphiphiles for solubilizing, isolating and characterizing membrane proteins. They can be prepared from cholic acid, deoxycholic acid and lithocholic acid, which are steroids found in bile.

The new amphiphiles, called CAO, DCAO and LCAO, are effective in challenging biochemical systems, such as extraction of delicate photosynthetic superassemblies from native lipid bilayers.
P09028US02
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