Explore WARF Inventions and Patents

WARF Technologies

WARF’s portfolio of more than 1,700 technologies covers a wide range of categories, including analytical instrumentation, pharmaceuticals, food products, agriculture, research tools, medical devices, pluripotent stem cells, clean technology, information technology and semiconductors.

Information summaries, which describe each technology and its applications, benefits, inventors and patent status, can be downloaded, printed and shared by clicking on the technology category links to the left on this page.

Visit our subscription center to sign up for our monthly email updates and learn when new WARF technologies become available for licensing.

New Inventions

Monomeric Fluorescent Protein-Ligand Complexes with Strong Fluorescence in the Far-Red Region

Research from the University of Wisconsin-Washington County in collaboration with the Institute for Stem Cell Biology and Regenerative Medicine in India, has resulted in the development of monomeric variants of the naturally occurring Sandercyanin Fluorescent Protein (SFP) using site-directed mutagenesis. This work has stemmed from earlier research focused on development of the tetrameric form of SFP, a biliverdin-binding lipocalin protein originally isolated from the mucus of the blue walleye fish, Sander vitreus. Monomeric variants of SFP (mSFPs) have been found to possess the same non-covalent, bili-binding characteristics of the tetramer but are one-quarter the size (~18.6kDa) and do not oligomerize. They are therefore anticipated to be more useful in a host of biotechnology applications. Like the tetrameric form, the mSFPs have a large stokes shift (375nm/675nm) and fluoresce in the far-red or near infrared region, which is advantageous for a wide range of applications including investigation of protein-protein interactions, spatial and temporal gene expression, assessing cell biology distribution and mobility, studying protein activity and protein interactions in vivo, as well as cancer research, immunology, and stem cell research and sub-cellular localization. In addition, the newly developed mSFP’s far-red fluorescence is particularly advantageous for in vivo, deep-tissue imaging.

Retinoic Acid: A New Treatment for Sleep Apnea and Hypopnea

UW–Madison researchers have developed a new method for treating sleep apnea and hypopnea with retinoic acid.

A patient can be given a retinoid or retinoic acid receptor agonist such as all-trans RA (ATRA), 13-cis RA (isotretinoin) or 9-cis RA (alitretinoin). These compounds target the mechanisms that cause sleep apnea in two ways. First, they increase the respiratory drive (urge to breathe). Additionally, they reduce the apneic threshold (the level of CO2 necessary for the induction of breath) to normal levels.

Improved System for Stroke Therapy and Rehabilitation

UW-Madison researchers have developed an improved system for stroke therapy and rehabilitation.  This system collects movement intention signals from the brain in real-time via EEG and initiates functional electrical stimulation (FES) of the appropriate muscle(s) to assist the neurons in regrowing their connections from the brain to the muscles along the correct pathways.  Additional general sensory stimulation may be added to this therapy to further encourage proper neuron regrowth. 

Temperature Gradient Handling System for Surface Plasmon Resonance (SPR) Measurements

Researchers in the Department of Chemistry and Biochemistry at the University of Wisconsin-La Crosse have developed a surface plasmon resonance (SPR) based method for measuring, in a single experiment, the temperature dependence of binding kinetics for biomolecular interactions. The method is based on a novel sample handling system that generates a spatial temperature gradient across an SPR sensor and is label free.

High Accuracy Angle Measuring Device for Industrial, Medical, Scientific or Recreational Use

A UW-Stout researcher has developed a high-accuracy angle measurement system that addresses the problems inherent to commercially available systems. In this novel device, a high accuracy rotary optical encoder is controlled by a microprocessor. The encoder consists of rotating optical disks and sensors that are precisely formed and placed to read angles with 0.001 arc second sensitivity (average) and better than ±0.1 arc second accuracy (single readings), which is comparable to the accuracy of the high-end commercial encoders currently on the market. This accuracy is maintained with strategies that combat the mechanical sources of error that are known disadvantages of other devices. The system can also be adjusted to compensate for any asymmetrical shifts that may occur. Mechanical sources of error and noise are further minimized by precision placement of disks and sensors, as well as low-friction reference points that keep components centered and level during rotation. In addition, multiple sensor heads eliminate major readout errors and remove the need for recalibration. All of these features and benefits are contained within a design that is both compact and portable. Beyond high accuracy and portability, the cost of this new angle measurement system is substantially lower than a high-end commercial system because it is easily constructed from readily available industrial grade components, bringing the production cost to roughly $2,000. Strikingly, this cost is comparable to the advertised price of other rotary position encoders that are less than one tenth as accurate. Its high accuracy, low cost, and portability make this new angle measurement system a strong option for use in virtually any of the current applications for absolute rotary encoders.
View More

New Patents

Superior Plastic Parts

UW–Madison researchers have developed a new method to create foamed, injection-molded plastic blends with significantly increased toughness and ductility compared to conventional foamed parts.

The new process begins with a polymer blend with two properly selected polymer materials, such as polypropylene (PP) and high-density polyethylene (HDPE), or PP and low-density polyethylene (LDPE), which exhibit a dispersed secondary phase at sub-microscale in the primary matrix. The polymer blend is heated along with a supercritical fluid in an extruder to produce a melt, which is then extruded into gas-laden pellets. The gas-laden pellets can be fed into the injection barrel of a typical machine, plasticized and then injected into a mold cavity (or cavities) where the final part is made.

The process forms a lightweight component with microscale air cavities. Upon tensile loading, debonding of the secondary phase facilitates the interconnection of microcellular voids to form channels such that the stretched component becomes a bundle of fibrils. Compared to other toughening methods, this method achieves a more significant improvement in ductility and toughness. It also has the benefit of higher production efficiency, better dimensional stability, and greater design freedom thanks to the foamed injection molding process.

Sustainable Organic Aerogels for Insulation

UW–Madison researchers have developed hybrid organic aerogels with desirable insulation properties. They are made by combining a water soluble polymer and a carbon nanofiller such as graphene oxide nanosheet with cellulose nanofibrilliated fibers (CNFs) derived from biomass. The organic polymer, such as polyvinyl alcohol (PVA), is cross-linked to form a gel and water is removed by freeze-drying. The surface of the aerogel can by further modified.

Solar Cells Track Sun

UW–Madison researchers have developed a passive solar tracking system utilizing materials that move in response to sunlight.

In the system, a solar cell panel is supported by flexible posts. The posts are made from a composite material, including a liquid crystal elastomer. This material has properties that cause it to contract and tilt when exposed to heat. To further exploit such properties, the material is embedded with carbon nanotubes that act as miniature heat sources, absorbing sunlight and giving off warmth.
View More