New Patents

Use of Peptides of Syndecan-1 to Inhibit Angiogenesis

UW–Madison researchers have developed a method of using a novel peptide from the extracellular domain of syndecan-1 to inhibit angiogenesis. The peptide interferes with the formation of new blood vessels by blocking the activation of αvβ3 and αvβ5 integrins. Recent in vivo mouse data shows that this peptide successfully inhibits angiogenesis and reduces tumor size without adverse side effects.
(Dec 20, 2016) P06390US02

Energy-Efficient Parallel Processing

A UW–Madison researcher has developed a technique to reduce the clock speed of spinning cores. This conserves energy during fine-grained synchronization events that would otherwise be fatally slowed by multiple system calls.

Specifically, clock dividers are provided on each core, allowing rapid changes in clock frequencies. A spinning core is slowed but still can operate in the environment of the other processors by making certain frequency adjustments. Power fluctuations that may result from abrupt clock speed changes can be minimized by disabling processor functions prior to the change.
(Dec 13, 2016) P140039US01

Energy-Efficient Multiplier Circuitry for GPUs

UW–Madison researchers have developed a new circuit system for multiplying floating-point numbers. The system combines a traditional floating-point multiplier with a power-of-two multiplier that works by shifting operations. Substantial power savings may be realized by selectively steering some operands to the power-of-two multiplier.

The different circuits have different advantages. The floating-point multiplier uses more power but is more versatile, while the power-of-two multiplier uses less power but is less versatile.
(Dec 13, 2016) P140267US01

Increasing Red Blood Cell Production

UW–Madison researchers have developed a method for increasing the production of red blood cells by knocking down certain components of the exosome (a protein complex inside cells that degrades RNA). Specifically, the new method uses an siRNA, ribozyme or other inhibitory nucleic acid molecule to decrease the expression of Exosc8, Exosc9, Dis3, Dis3L or Exosc10.

Knocking down these exosome components boosts genes and proteins that promote red blood cell development.
(Dec 6, 2016) P130326US02

Predicting Logic Gate Failure

UW–Madison researchers have developed a new fault prediction technique providing accuracy, generality and power efficiency. To do this, two similar circuit modules are used but one is artificially aged. Aging can be mimicked by lowering operating voltage and/or phasing a sampling clock to reduce slack time. Both approaches make the ‘aged’ gate more sensitive to delay. To achieve power efficiency, a novel technique is used to turn on this ‘mode’ at a low periodic rate.

The outputs of the two circuit modules is compared. Discrepancy in output indicates a projected failure.
(Nov 22, 2016) P130365US01

New Radiosurgery Collimator Salvages Scatter, Cuts Treatment Time

UW–Madison researchers have developed an SRS collimator assembly capable of refocusing scattered radiation that would otherwise be lost. The new design features concentric, conical slits oriented along different angles. Radiation striking the top surface of the collimator is redirected along each slit towards a common point, or isocenter.

The slits can be termed ‘Compton slits’ because they are designed to capture and redirect Compton scattered radiation.
(Nov 22, 2016) P140368US01

Memory Controller for Heterogeneous Processors

UW–Madison researchers have developed a memory controller providing improved access to common memory when a single parallel application is divided between different processor types, e.g., a CPU and a GPU. In these instances, fairness may not be a primary consideration and performance can be evaluated in terms of completing the entire application.

The controller works by dynamically adjusting access priorities between the different processors. It can predict sequential memory accesses by the processor having higher memory latency or fewer access requests to lockout the other processor during those sequences.
(Nov 22, 2016) P140398US01

More Efficient Signal Processing for Digital and Smartphone Cameras

A UW–Madison researcher has developed ISP circuitry than can operate in two modes. One mode optimizes the signal for human vision and the other mode optimizes the signal for feature/gesture recognition. The latter mode uses less energy because the image can be of lower quality.

The new ISP design conserves power by not processing each pixel value, operating all processing stages or sampling every frame.
(Nov 15, 2016) P150100US01

Lignin from Transgenic Poplar Is Easier to Process

UW–Madison researchers and others have developed genetically modified poplars with lignin that is less resistant to alkaline degradation.

Having previously identified and isolated the gene for FMT, the researchers introduced the nucleic acid sequence into poplar tissue. The enzyme produced lignin rich in monolignol ferulates, including coniferyl ferulate and sinapyl ferulate. The transformed lignin thus contained ester bonds that cleaved under relatively mild ammonia conditions.

The poplar cells were modified using standard genetic techniques.
(Nov 8, 2016) P100281US03

One-Step Process Turns Biomass into Hydrocarbon Building Blocks

UW–Madison researchers have developed a process for converting biomass to furfural-/HMF-ketone precursors that then may be turned into long-chain hydrocarbons.

The method, called HDA (Hydrolysis-Dehydration-Aldol condensation), streamlines several conversion processes into a single step. First, a ketone (like acetone) is used as a solvent with lithium bromide or other halide salt, water and acid. The mixture is reacted with biomass under mild conditions to yield furfural-/HMF-ketone adducts.

The adducts then may be converted into hydrocarbons by standard hydrodeoxygenation methods.
(Nov 8, 2016) P110018US02