New Patents

Multiphoton Flow Cytometer for High Throughput Analysis of Multicellular Aggregates Like Pancreatic Islets

UW-Madison researchers have developed a system that combines the high throughput characteristics of flow cytometry with the capabilities of MPLSM.  This multiphoton flow cytometry system (MPFC) enables deep, high resolution images of large diameter cells and aggregates. 

The multiphoton laser can excite intrinsic cellular fluorophores such as NADH, FAD and collagen, allowing both spectral and lifetime data to be acquired.  This information then can be used to reveal information on cellular processes like metabolism, viability and the functional potential of cells, pancreatic islets, embryoid bodies and other entities.
(Mar 28, 2017) P07386US

Portable Carbon Monoxide Source for Therapy and Organ Delivery

UW–Madison researchers have developed a portable carbon monoxide generator for medical use that creates precise, therapeutically relevant, concentrations of medical grade CO out of the surrounding air in real time. The device is inherently safe, as it produces only the amount of CO needed for therapy. The device is incapable of producing enough CO to pose a safety hazard.

The heart of the generator is a reaction chamber holding a small cartridge of purified carbon. The CO is produced by heating the carbon in the presence of air that is fed continuously into the reaction chamber. The carbon can be heated by any controllable energy source, such as an electrical filament or laser.

The amount of CO in the output stream is monitored by a sensor. Using feedback on both the gas flow rate and the heat source, the amount of CO generated is controlled to match the prescribed, adjustable value.
(Mar 28, 2017) P120148US01

Maximizing Multicore Processor Performance

A UW–Madison researcher has developed a solution for improving performance while still meeting a maximum power budget for multicore processors operating in a power-constrained environment.

The method provides for joint scaling of both the number of cores in operation as well as the amount of resources per core. Selecting the number of cores and the amount of resources is done by examining the degree of ILP and TLP available for a given application. As such, performance counters (and other characteristics) implemented by a processor are used to determine optimal core/resource configurations.

Performance counters may measure, for example, how many instructions are executed per cycle, length of execution time and cache hit rate. These performance measurements indicate how much ILP and TLP a given application exhibits at a time.
(Mar 28, 2017) P130137US01

Minimally Invasive Spinal Fusion

UW–Madison researchers have developed a method and surgical instrumentation to enable minimally invasive spinal fusion. In the procedure, a sharp pointed tube (a trocar) is inserted along the spine. Using the trocar as a guide, the bone graft material is pulled into place. The trocar is removed, releasing the graft in the desired location along the spine.
(Mar 28, 2017) P140303US01

Boron-Doped Diamond for Next Generation Power Electronics

UW–Madison researchers have developed a method to make boron-doped diamond via low-temperature thermal diffusion. The diamond material may be single crystalline, natural or type IIa.

In the process, an ultrathin boron-doped silicon nanomembrane is bonded to the surface of the diamond and annealed at a temperature around 800 degrees Celsius. Given enough time, the boron atoms from the nanomembrane diffuse into the diamond layer to form a doped region.
(Mar 28, 2017) P140384US01

Solar Cells Turn HMF to Valuable Platform Molecules

UW–Madison researchers have developed a new method using solar cells to electrochemically oxidize HMF to highly prized furan compounds, specifically FDCA (2,5-furandicarboxylic acid) and DFF (2,5-diformylfuran). These important compounds are used to produce polymer materials, pharmaceuticals, antifungal agents, organic conductors and much more.

The reaction takes place at ambient temperature and pressure using a TEMPO mediator. Unlike previous methods, the process does not require a precious metal catalyst.
(Mar 21, 2017) P150132US01

Methods of Using Redox-Active Surfactants to Control Polymer Interactions

UW-Madison researchers have developed superior transfection agents that allow spatial and temporal control over the delivery of nucleic acids to cells. These redox-active surfactants switch between a first oxidation state that promotes transfection of cells and a second oxidation state that is less effective at transfecting cells. The transformation between oxidation states is triggered by applying an electrochemical potential to the transfection agent, contacting the agent with an electron donor/acceptor or exposing the agent to an oxidative/reductive environment in a tissue. Redox-active surfactants are also capable of controlling the aggregation of polymers in solution by switching between an oxidation state that facilitates aggregation and one that does not.
(Mar 14, 2017) P05276US

Vernier Motor Uses Less Rare Earth Materials

UW–Madison researchers have developed a new vernier machine that outperforms other PMVM designs.

The new motor features a central rotor with spokes of magnets. The magnets can be ferrite-based or made of a minimal amount of rare earth material. The rotor is sandwiched by a pair of notched stators, each separated from the rotor by an air gap and wound by stator windings that form magnetic poles. In contrast to traditional PM machines, the number of rotor magnetic pole pairs is much greater than the number of stator winding pole pairs. Still, the motor is able to achieve smooth torque given its design.

In effect, the new design produces a rotating magnetic field that travels much faster around the air gap than the rotor. Increased rate of change of flux linkage means more voltage is induced.
(Mar 14, 2017) P130317US01

Palladium-Based Catalysts Herald Greater Efficiency of Alcohol Oxidation to Esters and Acids

Utilizing heterogeneous palladium-based catalysts with co-catalysts such as tellurium or bismuth, UW–Madison researchers have developed a new method for the efficient synthesis of esters and carboxylic acids from organic alcohols.

To form an ester, an organic alcohol is reacted, in the presence of oxygen gas, with methanol or ethanol. The reaction occurs in the presence of the palladium-based catalyst and the co-catalyst. To form an acid, water can be added to the reaction mix.
(Mar 14, 2017) P130355US02

Clearer MRI Near Metallic Implants

UW–Madison researchers have developed a new technique for faster, fully phase-encoded 3-D MRI that enables distortion-free imaging near metallic implants.

In the technique, multiple spectral bands associated with different resonance frequency offsets are simultaneously excited using a multiband excitation scheme. The MR signals generated in response to this excitation then are spatially encoded using phase-encoding along three dimensions. In other words, no frequency-encoding gradients are used.

The new technique can be referred to as multiband, fully phase-encoded (MB-FPE) imaging.
(Mar 14, 2017) P140004US01