New Patents

Environmentally Green Glue

UW–Madison researchers have developed a process to transform soy flour into a strong, environmentally safe wood adhesive.

In the process, a suitable reagent is used to phosphorylate the flour’s lysine amino acid residues. The phosphorylated flour then is mixed with an oxidizing agent that drives the formation of cross-linking bonds. This improves the flour’s adhesive properties. Unwanted salts created in the process can be removed.

Flours of other legumes and/or oil seed crops (e.g., flax, canola) are suitable as well.
(May 31, 2016) P130276US02

Treating Fungal Infections with New Forazoline Compounds

UW–Madison researchers have developed antifungal compounds isolated from Actinomadura, a bacterium found in a species of sea squirt. After extensive chemical isolation and characterization, the researchers identified a new class of compounds called ‘Forazolines’ that possess antifungal activity. Forazoline A was shown to be effective against Candida albicans in a mouse model.
(May 24, 2016) P130274US02

Protecting Ovaries from Chemotherapy Damage Using Proteasome Inhibitors

UW–Madison researchers have developed a method to reduce ovarian damage in cancer patients by administering a proteasome inhibitor prior to chemotherapy.

The inhibitors work by binding to a cell’s proteasome –the large complex of enzymes found in the cytoplasm that degrades and disposes old proteins. This binding action blocks chemotherapeutic agents from invading the cell nucleus.

To shield ovaries from chemotherapy toxicity, an effective dose of a proteasome inhibitor like bortezomib (Bort) or MG-132 is injected about an hour before treatment.
(May 10, 2016) P130111US02

Ultrawide Band, Low-Profile ‘Stacked’ Antenna System

UW–Madison researchers have developed a compact, ultrawide band antenna system with monopole-like radiation characteristics and a bandwidth of 10:1. The system is designed with two antennas wherein one is a scaled-down version of the other. The two antennas can ‘stack’ or ‘nest’ to be less conspicuous. A feed network feeds the appropriate antenna based on the frequency of the input signal. This enables the design to work as a single, ultrawide band system.
(May 10, 2016) P140308US01

Short-Pulsed Alkali Magnetometer for Precision in Ambient Fields

UW–Madison researchers have developed a method of spin polarization using an AC-coupled short pulse, permitting ultrasensitive magnetometry in the presence of Earth-level magnetic fields. By suppressing the spin-relaxation due to interactions between the instrument’s alkali atoms, the short pulses attain high transverse spin polarization free of dephasing collisions.

With increased sensitivity, the new design permits detection of minute fluctuations on par with other alkali-based magnetometers that require a near zero magnetic field environment.

The magnetometer includes a gas chamber exposable to an external magnetic field. An electromagnet is positioned to apply a local magnetic field to the chamber. By modulating the rotational change of the alkali atoms with a controllable time-dependent magnetic field, the atoms can be retained in a state in which collisions do not dephase their magnetic orientation.
(May 3, 2016) P110354US01

Producing Medical Isotopes with Dry-Phase Reactor

UW–Madison researchers have developed an improved method for generating medical isotopes using a dry-phase granular uranium compound, such as uranium salt or oxide.

In the process, the dry granular uranium is exposed to radiation that produces medical isotopes by nuclear reaction. The irradiated uranium then is dissolved in a solvent and the desired isotopes are extracted using standard aqueous separation techniques. The granular uranium material can be dried and reused.
(May 3, 2016) P120306US01

High-Resolution R2 Mapping with Chemical Species Separation

UW–Madison researchers have developed a method for producing a quantitative map of R2* while separating signal contributions from two or more chemical species, like fat and water.

The method works by producing quantitative R2* maps, quantitative fat fraction maps and separate R2*-corrected water and fat images. A low-resolution field map and a common water-fat phase are used to demodulate the effects of these parameters from the acquired data while separating the water and fat signals.

In this way, water, fat and R2* can be estimated simultaneously. A full resolution R2* map is reconstructed in addition to water, fat and fat fraction images that are corrected for the effects of R2*.
(May 3, 2016) P120316US01

New Mass Spectrometry Detector Uses Optically Active Membrane

UW–Madison researchers and collaborators have developed a mass spectrometry detector that is more sensitive to large molecule impacts and may provide better spatial sensitivity. The detector incorporates a thin membrane made of semiconducting materials. The membrane is optically active, converting the kinetic energy of the molecules that strike its front surface into light photons. The photons are detected and converted to an electrical signal by a photosensor.
(May 3, 2016) P140174US01

Manufacturing Polymer Micropellets

A UW–Madison researcher has developed a micropelletizing method and apparatus for controlling the size and shape of polymer particles.

In the process, a thin melt of polymer material is extruded through a specialized nozzle. A jet of heated, pressurized air then is applied. This causes the thread to stretch and break up into individual droplets due to surface tension effects known as Rayleigh disturbances.

The droplets are allowed to cool and solidify into micropellets. Factors like temperature, speed and extrusion rate are used to control droplet formation.
(Apr 26, 2016) P100314US02

Enzyme Aids Intranasal Drug Delivery

UW–Madison researchers have developed a method to enhance intranasal drug absorption using a naturally occurring endopeptidase, called matrix metalloproteinase-9 (MMP-9). This enzyme makes the nasal epithelium more permeable to drugs by degrading type IV collagen. Nasal spray or drops containing MMP-9 can be administered at the same time or prior to a drug to improve its absorption.
(Apr 26, 2016) P120322US02