Through Technologies

New Patents

Cranberry Variety Trade Named "Sundance," with Large Berry Size and Favorable Bud Set Traits

UW–Madison researchers have developed a new variety of cranberry with the trade name “Sundance.” This variety was developed through a cross of the “Stevens” cultivar and a seedling selection of “Ben Lear” that offers significantly improved traits over its “Ben Lear” parent. “Sundance” is superior to the predominant cranberry cultivar “Stevens” in fruit size, overall coloration, yield potential and flower bud set. Also, under high crop loads, “Sundance” tolerates high levels of fertilizer to improve yield and flower bud set without causing excessive vine growth. Researchers believe that the improved fruit quality of “Sundance,” specifically larger size and solid cell structure, will result in an improved variety for sweetened dried cranberry production.

Growers interested in this cranberry variety should license the variety from WARF and obtain vines from one of the approved propagators listed below. The license between WARF and the grower must be in place before vines can be obtained.
  • Cranberry Creek Cranberries Inc.
  • Dempze Cranberry Co.
(Nov 18, 2014) P100154US01

Gravity- and Pressure-Controlled Valve System for Controlling Cerebrospinal Fluid in the Ventricular System

UW–Madison researchers have developed a system that allows drainage of excess CSF and prevents CSF overdrainage. A key insight is that cardiac pulsations can be transmitted inside the shunt tubing, creating a pulsatile pressure wave that propagates down the tubing. When this pressure wave hits a pressure differential valve, it can force the valve open during the systolic phase of the pressure wave, pumping some CSF through the valve with each systolic phase. In this way, CSF can be pumped across a valve as long as the peak pressure within the shunt tubing exceeds the preset pressure differential threshold for that valve, even if the mean pressure is below that same threshold. Overdrainage then occurs. The improved system and valve design prevent slit ventricle syndrome by addressing both gravity siphon effects and cardiac pulsations.

The improved system consists of tubing that leads from the ventricular system into a valve system that has two arms, a forward flow arm and a return flow arm. A one-way low threshold pressure differential valve is located in the forward flow arm. CSF that passes this first valve can either exit the valve system through a one-way higher threshold exit valve that leads into the peritoneal cavity, or it can flow through the return flow arm via a one-way low threshold valve that returns CSF back to the inlet side of the valve system. By choosing appropriate pressure differentials for the three valves, one can bracket the pressures on the inlet side between a set minimum and maximum value. If the ICP rises above the set maximum, then CSF will flow through the inlet valve and out the exit valve. If the ICP drops below the set minimum, then CSF will flow through the return valve and back towards the inlet side of the valve system, thus preventing overdrainage. The high threshold pressure differential exit valve also incorporates a gravity compensation unit that negates the gravity siphoning effect, regardless of the orientation of the patient. Thus, the net effect is to allow for drainage of excess CSF while preventing overdrainage due to either the cardiac pulsation or gravity siphon effect.
(Nov 4, 2014) P110042US01

VeA, a Global Regulator of Secondary Metabolism, Can Increase Production of Secondary Metabolites

UW-Madison researchers now have identified another global regulator of secondary metabolism, called VeA.  VeA is a conserved protein that interacts with LaeA in an as yet unknown mechanism.  Overexpression of veA upregulates secondary metabolism in A. flavus to a greater degree than overexpression of laeA.  This gene could be used to increase the production of important natural products, including novel products with medicinal value.
(Oct 28, 2014) P09056US02

Low-Noise, Phase-Insensitive Linear Amplification at Microwave Frequencies

UW–Madison researchers have developed a system and method for a low-noise, phase-insensitive linear amplifier capable of accommodating readout signals from quantum computing applications, even when such signals reach frequencies in the RF and microwave range. The amplifier can improve signal-to-noise ratio significantly by incorporating a low-inductance device geometry that is compact, straightforward to model at microwave frequencies and readily integrated into an RF or microwave transmission line environment. The device’s input and output can be matched to transmission-line impedances.

The amplifier system includes an input providing a direct coupling configured to receive a high-frequency input signal. The system also includes an amplifier containing a dielectric material separating superconducting layers, forming an amplifier loop configured to receive the input signal and deliver an amplified signal. The system includes an output providing a direct coupling configured to deliver the amplified signal. A quantum information processing network is configured to receive and relay high-frequency signals. The network includes a signal source, a source of qubits and a linear cavity resonator. The network also includes a transmission line communication system configured to transmit and receive the high-frequency signal, and an amplifier coupled directly to the transmission line communication system through an input and output.
(Oct 14, 2014) P120028US01

Method for Quantification of R2* Relaxivity in Magnetic Resonance Imaging

UW–Madison researchers have developed a method for measuring R2* with MRI in which signal decays that occur as a result of macroscopic variations in the main magnetic field of the MRI system are incorporated into a chemical-shift based signal model. The model provides for the mitigation of errors due to macroscopic field variations and allows better signal-to-noise ratio performance compared to existing R2* measurements.

The method samples echo signals occurring at different echo times to acquire MRI image data. For each of the echo signals, a signal model is formed to account for relative signal components for each different chemical species, such as water and fat. Magnetic field inhomogeneity values associated with the MRI system are estimated by fitting the acquired image data to the signal models. This allows the creation of signal models that account for relative signal components for each different chemical species and signal decay resulting from macroscopic variations in the main magnetic field of the MRI system. The method also allows estimation of R2* for at least one of the chemical species by fitting the acquired image data to the signal models.
(Oct 7, 2014) P110135US01

Electrically Small, Super-Directive Antennas Inspired by Insect Anatomy

A UW–Madison researcher has developed an electrically small array that converts super-resolving antennas to super-directive antennas by utilizing a phase shifter. The resolution enhancement increases the total amount of collected power and the overall signal-to-noise output.

The receiver system includes two antennas and a processing circuit with a differential phase shifter (DPS). The second antenna receives a signal, which then is phase shifted as a function of its angle of incidence relative to the array’s boresight axis. An output signal can be configured by combining the phase-shifted signal with the first antenna’s original signal.

Three distinct DPS methods can achieve the same result. Active DPS can be implemented using a mixer, filters, amplifiers and voltage controlled phase shifter. Direct DPS is another analog process, while digital DPS samples and processes the antenna signals digitally.
(Sep 30, 2014) P120184US01

More Efficient and Reliable High Power Quantum Cascade Lasers

UW–Madison researchers have developed a design to reduce threshold-current density and virtually suppress electron leakage using certain multiquantum well structures in the active regions of QCL devices. The structures are designed to work reliably over long periods of time at high efficiency and power (i.e., watt range) during quasi-continuous or continuous wave (CW) operation.

Known methods may be used to fabricate the semiconductor structure and laser devices and to form the electron injector, active region and electron extractor. The active region features a series of quantum wells and barriers of various alloy compositions. The energies of the first and second barrier in the active region are less than the third barrier.
(Sep 30, 2014) P120315US01

Multilayered Film for Delivering Proteins and Other Small Molecules into Cells

UW-Madison researchers have developed a new way of delivering proteins and other small molecules into cells. This approach uses a cationic “anchor” to improve incorporation of proteins into multilayered films.

Before the protein or small molecule is integrated into the film, a cationic protein transduction domain, such as nonaarginine, is attached to it. Appending short, cationic peptides or oligomers to proteins can facilitate their layer-by-layer assembly into PEMs, as well as their uptake by cells.

Then the cationic molecule is incorporated into a polyelectrolyte multilayered film, along with anionic polymers such as sodium polystyrene sulfonate, to result in a multilayered assembly that is preferably about 80 nanometers thick. When this composition is presented to a cell, the film dissolves, delivering the molecule to the cell.
(Sep 16, 2014) P07251US

High-Symmetry, Bicontinuous Lyotropic Liquid Crystals with Percolating Nanoscale Domains

UW–Madison researchers have developed a new class of anionic Gemini amphiphiles based on aliphatic carboxylic acids that exhibit a strong propensity to form G-phase LLC assemblies in an aqueous solution. Moreover, these G-phases are broadly stable between 25 and 100 degrees Celsius and across a wide range of amphiphile concentrations (up to 20 weight percent).

The LLC-forming material comprises water or another polar solvent and an anionic Gemini (“twin tail”) surfactant containing at least one carboxylate moiety. This scaffold furnishes ready access to useful, high-symmetry Q-phase LLCs having well-defined pore wall functionalities that can be readily tuned by chemical synthesis for specific applications.
(Sep 16, 2014) P120009US01

Easy Test for β-lactoglobulin (BLG) Milk Allergen

UW–Madison researchers have developed a simple, rapid test for detecting and quantifying BLG in food. Their method takes advantage of the fact that current signals passed through a hydrogen peroxide solution will be diminished if BLG is present.

Specifically, a known concentration of hydrogen peroxide is added to a sample suspected of containing BLG. The sample is electrolyzed using a working electrode at a fixed potential sufficient to electrolyze any BLG. The current signal within the sample is measured and compared to control curves. If BLG is present, the signal will be smaller than expected. The more the signal is diminished, the greater the concentration of BLG in the sample.
(Sep 16, 2014) P120220US01