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April 21 @ 2:00 pm - 5:00 pm
Join WARF Therapeutics, the UW-Madison Department of Chemistry and the UW-Madison Synthesis and Catalysis Center for a symposium that will highlight innovative chemistry and its integration into pharmaceutical discovery and manufacturing.
Grace Lutovsky, Yoon Group
Photoactive Cu(II) and Fe(III)Carboxylates Enable a VersatileP latform for C–N, C–O and C–C Bond Formation
Edward Pimentel, Martell Group
DNA Architectures to Accelerate and Optimize Synergistic Catalysis
Diana Wang, Wickens Group
Coupling Alkenes and Amines via a Dication Pool Approach
Accelerating Medicinal Chemistry Through High Throughput Experimentation – Nicole Goodwin, GlaxoSmithKline
High throughput experimentation (HTE) has had a revolutionary impact on the pharmaceutical industry. Automation and miniaturization of chemistry activities down to the microliter-sized reaction have allowed for increased efficiencies in reaction development, parallel synthesis and other enabling technologies that innovate and drive success in our discovery chemistry groups. Today’s seminar will describe the modern methods that GSK implements in this space and feature their application in an end-to-end nanoscale direct-to-biology workflow (D2B) that allows for simultaneous large-scale optimization of chemical diversity against reaction conditions in a single experiment. These crude reaction mixtures are progressed directly to in vitro biological screening. Validation of this workflow against GSK’s Protacs platform will be presented.
Strategic Chemical Synthesis with Data Science – Timothy Cernak, University of Michigan
Advancing the synthesis of small molecules is critical to the advent of new medicines, materials and agrochemicals. Our lab has been exploring strategies in chemical synthesis – both in reaction method development and total synthesis – that leverage modern data science techniques. This presentation will share some recent results using informatics to target novel amine–acid coupling reactions, and algorithms to streamline the total synthesis of alkaloids. Chemical synthesis enabled by data science techniques and automation will be a consistent theme of the research.
This event will be held in person at the Chemistry Learning Studio. The entrance is at the corner of Mills Street and University Avenue.