Wisconsin Alumni Research Foundation

Technology

Natural Antibiotic to Treat Clostridium Infection and More

Bacterial resistance to antibiotics is an escalating problem, especially in hospital settings. The Centers for Disease Control recently identified Clostridium difficile as posing an “urgent” healt...
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Timothy Bugni, Thomas Wyche, Douglas Braun, Jeff Piotrowski, Nasia Safdar | P140428US02

Technology

Compound Combination Targets Bacterial Virulence

Many common bacterial pathogens delay virulence factor production until there is a sufficient number of cells that – working together – can overwhelm a host’s defense. To coordinate such...
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Helen Blackwell, Michael Welsh | P160176US02

Technology

Nylon-3 Polymers Active Against Clostridium Difficile

Clostridium difficile is a Gram-positive, endospore-forming anaerobe that causes life-threatening intestinal infections. These infections result in more than 14,000 deaths and billions of dollars in h...
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Samuel Gellman, Runhui Liu, Bernard Weisblum, Shonna McBride | P150214US02

Technology

Compound to Treat Staphylococcus aureus Infections Including MRSA Strains

Emerging resistance to antibiotics remains a serious threat to human health. The Centers for Disease Control and Prevention (CDC) estimates that each year nearly 2 million people acquire an infection ...
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Aaron Monte, William Schwan, Marc Rott, James Cook, M. Shahjahan Kabir, Jennifer Miskowski, Ranjit Verma, Leah Defoe | T100005US02

Technology

New Broad-Spectrum Antibiotics

The rise of antibiotic-resistant bacteria represents a potential health crisis. Some antibiotics (e.g., quinolones and fluoroquinolones) are losing their effectiveness while others simply don’t ...
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Douglas Weibel, Katherine Hurley, Katherine Faulkner | P140321US02

Technology

Combatting Biofilms by Disrupting Bacteria Quorum Sensing

Bacteria can grow into harmful communities called biofilms that are present almost everywhere on earth – from hospitals to food facilities. Biofilms are especially difficult to clear because they ar...
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Helen Blackwell, Reto Frei, Anthony Breitbach, David Lynn, Adam Broderick | P110358US02

Technology

A Supply of the Antibiotic Oligomycin

Oligomycin is a highly stable macrolide antibiotic isolated from the fungus Streptomyces diastochromogenes. It is a potent inhibitor of mitochondrial ATPase and phosphoryl group transfer.
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Glenn Chambliss | P04054US

Technology

Method for Modulating Microbial Quorum Sensing

Bacteria that use quorum sensing are thought to be involved in two thirds of human bacterial infections. These bacteria produce acyl-homoserine lactones (AHL), which they use to gauge population densi...
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Jo Handelsman, Bradley Borlee | P04217US02

Technology

Antibacterial Agents Using Small Molecule Macroarrays

Staphylococcus aureus is a Gram-positive bacterium responsible for many infectious diseases, including toxic shock syndrome, food poisoning and topical skin infections. Although S. aureus is usually a...
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Helen Blackwell, Matthew Bowman, Jennifer Campbell Butler, Joseph Stringer | P06361US

Technology

Antimicrobial Polymers

The emergence of bacteria that are resistant to common therapeutic agents has resulted in a dire need for new antimicrobial compounds. One potential source of new antimicrobials is amphiphilic pe...
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Samuel Gellman, Michael Gelman, Bernard Weisblum, David Lynn | P03315US

Technology

Receptor For Bacillus anthracis Toxin

Infection with Bacillus anthracis, the spore-forming causative agent of anthrax, can result in either a generally benign, self-limiting cutaneous disease or a more serious and often fatal systemic dis...
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John Young, Kenneth Bradley, R. John Collier, Jeremy Mogridge | P00305US

Technology

Novel Antibacterial Small Molecules

As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
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Helen Blackwell, Matthew Bowman, Joseph Stringer | P07517US

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