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10 Results for 'Biologics'
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Technology
METHODS OF INDUCING CARDIAC CELL PROLIFERATION AND INDUCING HEART REGENERATION
UW-Madison researchers have discovered that inducing expression of the protein LRRC10 in mouse hearts promotes heart regeneration. Neonatal mice have hearts that naturally regenerate for the first wee...
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Ahmed Mahmoud, Timothy Kamp, Youngsook Lee | P230238US02
Technology
IDENTIFICATION AND APPLICATION OF SELECTIVE CELL SURFACE MARKERS AND ADDITIONAL METHODS FOR HUMAN RED/GREEN CONE PHOTORECEPTOR PRECURSOR ENRICHMENT
UW-Madison researchers have discovered a cell-surface marker (CD166) that can be used to distinguish (and purify) cells that are immature (early) cone photoreceptor precursor cells (CPPs), which will ...
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David Gamm, Praveen Joseph Susai Manickam, Michael Phillips, Elizabeth Capowski | P220285US02
Technology
Ph-Responsive Nano Particle For Delivery Of Ribonucleoproteins
UW researchers have developed a polymeric nanoparticle to package and deliver a CRISPR/Cas protein/guide RNA complex and, optionally, a single stranded DNA repair template into cells for gene therapy....
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Shaoqin Gong, Ruosen Xie, Xiuxiu Wang | P210402US02
Technology
Lipopeptides, Nanoparticles and Methods Of Use
UW-Madison researchers have developed a novel lipid nanoparticle for delivering biomolecules. The researchers designed the lipopeptide-based nanoparticle for efficient delivery of various biomolecules...
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Shaoqin Gong, Min Zhu, Xianghui Xu | P230065US02
Technology
Targeting Cancer Therapeutics and Diagnostics with Camelid Antibodies That Bind FAP
Fibroblast Activation Protein (FAP) is expressed in 90% of all solid tumors, making it an attractive target in cancer. Current small molecules targeting FAP clear from the system too rapidly, and FAP-...
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Aaron LeBeau, Joseph Gallant | P230173US01
Technology
GENERATION OF NEXT GENERATION RECOMBINANT AAV GENE THERAPY VECTORS THAT ADOPT 3D CONFORMATION
UW-Madison researchers have developed approaches to improve recombinant AAV gene therapy vectors (rAAV) therapies by improving their expression in target cells. The inventors have discovered that the ...
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Kinjal Majumder, Clairine Larsen | P220260US02
Technology
SIRPĪ± Inhibited Macrophages and Neutrophils and Uses Thereof
UW-Madison researchers have developed methods for generating SIRPα-KO macrophages with superior anti-tumor activity, and SIRPα-knockout neutrophils with superior anti-bacterial and anti-tu...
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Igor Slukvin, Portia Smith, Aditi Majumder, Anna Huttenlocher, David Bennin | P220110US02
Technology
pH-Responsive Nanoparticle For Delivery Of Ribonucleoproteins
UW researchers have developed a polymeric nanoparticle to package and deliver a CRISPR/Cas protein/guide RNA complex and, optionally, a single stranded DNA repair template into cells for gene therapy....
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Shaoqin Gong, Ruosen Xie, Xiuxiu Wang | P210402WO01
Technology
Anti-CD40 Single-Chain Variable Fragment And Human IL-21 Fusion Protein (CD40SCFV-IL-21)
UW-Madison researchers have developed a novel fusion protein for inducing Breg cell formation and a method for transforming any human B cell into an IL10-competent, functional Breg cell ex vivo at sca...
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Jacques Galipeau, Andrea Pennati, Shala Yuan | P210323WO01
Technology
DERIVATION OF HEPATOCYTES AND HEMATOPOIETIC PROGENITORS FROM HUMAN EMBRYONIC STEM CELLS
The inventors have developed a novel system for co-differentiation of hepatocytes and hematopoietic progenitors from human embryonic stem cells (ES cells) that mimics a late fetal liver undergoing hem...
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James Thomson, Srikumar Sengupta | P210190US02