Wisconsin Alumni Research Foundation

Technology

UW-Madison researchers have developed a titin DNA construct (a ‘titin minigene plasmid’) that is useful for identifying agents that modulate the titin size reduction that correlates with a...
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Wei Guo, Yanghai Zhang | P230097US01

Technology

Automated Imaging System For Single Molecules

There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure al...
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David Schwartz, Rodney Runnheim, Daniel Forrest | P02230US

Technology

A Method To Determine The Throughput Speed Of A Pore

A method (100) can be provided to determine the throughput speed v of at least one pore (1), comprising: • feeding (110), using a driving force F, a filiform calibration element (2) through the pore...
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Robert Blick, Paul Gwozdz, Abhishek Bhat | P160202US02

Technology

System And Method For En Masse Patterning Of Molecule Structures

Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be con...
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David Schwartz, Kristy Kounovsky-Shafer, Juan Hernandez-Ortiz, Konstantinos Potamousis, Kyubong Jo, Juan DePablo, Theo Odijk | P170209US02

Technology

Nanocapsule Delivery System For Ribonucleoproteins

With the explosion of interest in using the CRISPR/Cas9 system for gene editing, there is a strong focus on developing tools for delivering the CRISPR machinery safely and efficiently into cells. Exis...
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Shaoqin Gong, Krishanu Saha, Guojun Chen, Amr Abdeen, Yuyuan Wang, Ruosen Xie | P170376US02

Technology

Nuclease Inhibitors and Methods for Their Use

Biochemical research and biotechnology rely on nucleic acids; however, nucleic acids frequently encounter nucleases that can negatively affect experiments. Although nuclease inhibitors are often used ...
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Ronald Raines, Bryan Smith, David Lynn, Matthew Soellner | P05096US

Technology

S1mplex: A New Tool for Precision Gene Editing

New tools for human gene editing are rapidly advancing all sectors of biomedicine from basic biology to somatic gene therapy in the clinic. Precise editing of DNA sequences in the human genome can be ...
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Krishanu Saha, Jared Carlson-Stevermer, Amr Abdeen, Lucille Kohlenberg | P170309US02

Technology

Titin Minigene: Cardiac Research Tool

Titin is a sarcomeric protein expressed primarily in striated muscles. It is responsible for maintaining the structure and biomechanical properties of muscle cells. In the heart, cardiac titin under...
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Marion Greaser, Shijun Li, Wei Guo | P170288US01

Technology

Streamlined Design for Transferring Analytes

Polymerase chain reaction (PCR) is used to generate copies of a particular DNA sequence. The technique is common and indispensable in many research applications. Unfortunately, methods for isolating/p...
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David Beebe, Ben Casavant, David Guckenberger, Scott Berry | P130361US01

Technology

Poly(UG) Polymerase: A Useful New RNA Tool

Enzymes called ribonucleotidyl transferases (NTases) add nucleotides to the ends of RNAs. At present only a few such enzymes are known, such as poly(A) polymerases and poly(U) polymerases. The selecti...
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Marvin Wickens, Melanie Preston | P140268US02

Technology

Nanopore Antennas for Ultrahigh Speed DNA Sequencing

‘Nanopore sequencing’ allows a single molecule such as DNA to be analyzed without conventional tools like chemical labels or costly optical instruments. In the process, DNA strands and a stream of...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P140109US01

Technology

Synthesis of High-Density Oligomer Microarrays

To save time and costs, many alternatives to conventional DNA sequencing have been proposed. One approach utilizes an array of oligonucleotide probes (short nucleic acid chains) synthesized by photoli...
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Franco Cerrina, Viktoriya Golovkina | P05183US

Technology

New Protein Production Strategy for Plants

In animals, plants and other eukaryotic organisms, typically one protein is translated from each mRNA. Usually, translation can start only at one end of the mRNA strand. In contrast, several viruses ...
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Aurelie Rakotondrafara, Jincan Zhang | P140069US02

Technology

Computer-Based Determination of Haplotype

Humans are diploid organisms whose (non-sex) cells contain two copies of each chromosome – one from each parent. Each of these two copies may be distinguished by genetic variations such as insertion...
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Tom Anantharaman, Bud Mishra, Will Casey | P05170US

Technology

Device Uses Air Gap for Easier Fraction Isolation

Isolating analytes from complex biological samples is one of the most crucial steps in many areas of biological research and clinical diagnostics. Paramagnetic particles (PMPs) or beads are important ...
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David Beebe, Scott Berry | P130107US01

WARF