Wisconsin Alumni Research Foundation

Technology

Vancomycin Analogs And Method Thereof

The present invention teaches rapid diversification of vancomycin analogs through glycorandomization and chemoenzymatic strategies resulting in a diverse library of complex natural product architectur...
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Jon Thorson | P04451US

Technology

Neoglycorandomization And Digitoxin Analogs

The present invention provides methods of producing libraries of compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred...
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Joseph Langenhan | P08057US

Technology

Method Of Preparing Botulinum Neurotoxin Type A Light Chain

The present invention provides a preparation of botulinum toxin light chain type A or E, wherein the preparation is both catalytically active and soluble. Preferably, the preparation consists essentia...
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Eric Johnson, Marite Bradshaw, Joseph Barbieri, Michael Baldwin | P04467US

Technology

Research Tool for Protein Conformation Analysis

The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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Michael Sussman, Juda Shohet, Faraz Choudhury, Joshua Blatz, Benjamin Minkoff, Daniel Benjamin | P160180US02

Technology

Yeast-Based Intein Platform for Drug Production

The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
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Eric Shusta, Cathryn Marshall | P150056US02

WARF