Cell therapy is a novel and promising approach to treating diseases such as rheumatoid arthritis, atherosclerosis, acute ischemia, myocardial infarction, diabetes, graft versus host disease and cancer...
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UW-Madison researchers have identified several tryptophan decarboxylase (TDC) mutations for improving enzymatic activity towards substituted tryptamines. Having identified these mutations, the researc...
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UW-Madison researchers have developed a protein-based method for selective deuteration of amino acids. The inventors’ method leverages the aminotransferase DsaD, a PLP-dependent enzyme, and a sm...
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UW-Madison researchers have identified novel ACE2 mutants having enhanced activity and/or specificity in hydrolyzing angiotensin II. ACE2 (angiotensin converting enzyme 2) is a key metalloprotease of ...
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Building off of their prior discovery (Photo-Cleavable Surfactants P180335US02), UW-Madison researchers disclose an improved method for exosome proteomics. The method leverages the researchers’ ...
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UW-Madison researchers have developed a titin DNA construct (a ‘titin minigene plasmid’) that is useful for identifying agents that modulate the titin size reduction that correlates with a...
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UW-Madison researchers disclose a new method for differentiating brain mural cells – encompassing pericytes and vascular smooth muscle cells – from hPSCs. The inventors used their previous...
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Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining g...
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UW-Madison researchers have cloned, sequenced and characterized the genome from an isolate of the RV-C45 genotype, and they’ve provided the cDNA for a high titer HRV-C (C45-2A-D41K), as well as ...
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UW-Madison researchers have developed two cell lines derived from RPE-1 cells (which were obtained from ATCC), an immortalized, non-transformed human epithelial cell line. “PLK4 WTflox/Delta&rdq...
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HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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Vasoconstrictors are administered topically to provide protection against the adverse effects, e.g., alopecia, mucositis or dermatitis, induced by chemotherapy or radiotherapy. Appropriate dosages and...
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Human rhinoviruses (species A, B and C) are responsible for the majority of upper respiratory tract infections (like the common cold) and many infections of the lower respiratory tract as well. Rhin...
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Amyotrophic lateral sclerosis (ALS) is a devastating disease with no effective treatment. In patients with ALS, the neurons in their brains degenerate, leading to cognitive and physical breakdown. Oth...
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Maintaining an adequate supply of oxygen to tissue is necessary for survival. The oxygen-carrying capacity of blood is governed by the concentration of red blood cells (erythrocytes). It is critical t...
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Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. SCDs may influence the development of diseases such as obesity, atherosclerosis and diabet...
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The SCN5A gene encodes a human cardiac sodium (Na+) channel alpha subunit that carries the inward Na+ current in the heart. Three distinct polymorphic SCN5A clones, hH1, hH1a and hH1b, have been isola...
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The antibiotic vancomycin targets the peptidoglycan-containing bacterial cell wall. Inducible resistance to vancomycin and other glycopeptide antibiotics is becoming a serious health problem, necessit...
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In patients who develop breast cancer, malignant tumors frequently begin in somatic mammary stem cells. In addition, breast tumors have a stem cell component that propagates the tumor, which may expla...
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Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. Inhibitors of SCD may be useful therapeutics for diseases such as obesity and diabetes.
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Approximately one-third of the world’s population is infected with the bacterium Mycobacterium tuberculosis, the causative agent of tuberculosis (TB).  Five to 10 percent of non-immunocompr...
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Johne’s disease is a contagious, chronic and usually fatal wasting disease that primarily affects the small intestine of ruminants. It is a worldwide problem with no known treatment and infects ...
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