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106 Results for 'Pluripotent Stem Cells'
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Technology
Feeder Independent Extended Culture Of Embryonic Stem Cells
Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells...
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James Thomson, Ren-He Xu | W04001US
Technology
MYELOPOISIS FROM STEM CELLS
A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed.
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Igor Slukvin, Maksym Vodyanyk, Kyung-Dal Choi | P09078US02
Technology
METHOD FOR CULTURING STEM CELLS
A three-dimensional microwell system that supports long term pluripotent cell culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured pluripotent cells remain viabl...
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Timothy Kamp, Jianhua Zhang, Jeffrey Mohr, Juan DePablo, Sean Palecek | P08310US02
Technology
PLURIPOTENT STEM CELLS OBTAINED BY NON-VIRAL REPROGRAMMING
Methods for reprogramming primate somatic cells to pluripotency using an episomal vector that does not encode an infectious virus are disclosed. Pluripotent cells produced in the methods are also disc...
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James Thomson, Junying Yu | P09113US02
Technology
In Vitro Model Of Spinal Muscular Atrophy
A population of iPS cells derived from somatic cells from a spinal muscular atrophy patient is disclosed. In one embodiment of the invention, the cells have been cultured to produce neural cells. In a...
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Clive Svendsen, Allison Ebert | P09194US02
Technology
GENERATION OF CLONAL MESENCHYMAL PROGENITORS AND MESENCHYMAL STEM CELL LINES UNDER SERUM-FREE CONDITIONS
Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.
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Igor Slukvin, Maksym Vodyanyk, Junying Yu, James Thomson | P07264US
Technology
MEDIUM CONTAINING PIPECHOLIC ACID AND GAMMA AMINO BUTYRIC ACID AND CULTURE OF EMBRYONIC STEM CELLS
Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells...
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Tenneille Ludwig, James Thomson | P04124US
Technology
Oct4 And Sox2 With Sv40 T Antigen Produce Pluripotent Stem Cells From Primate Somatic Cells
Methods for reprogramming primate somatic cells to pluripotency using an episomal vector that does not encode an infectious virus are disclosed. Pluripotent cells produced in the methods are also disc...
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James Thomson, Junying Yu | P09113US04
Technology
Hydrogel Compositions For Use In Cell Expansion And Differentiation
Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiatio...
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William Murphy, Matthew Parlato, Ngoc Nhi T. Le, James Molenda | P150263US01
Technology
Hydrogel Compositions For Use In Promoting Tubulogenesis
Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell ...
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William Murphy, Eric Nguyen, Michael Schwartz, Hamisha Ardalani, Matthew Zanotelli, Matthew Parlato, David Belair, William Daly, Ngoc Nhi T. Le, Stefan Zorn | P140314US02
Technology
Methods Of Maintaining, Expanding, And Differentiating Neuronal Subtype Specific Progenitors
Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present in...
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Su-Chun Zhang, Zhong-wei Du | P150190US02
Technology
Simplified Basic Media For Human Pluripotent Cells
Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS c...
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James Thomson, Guokai Chen | P120133US01
Technology
Methods And Devices For Differentiating Pluripotent Stem Cells Into Cells Of The Pancreatic Lineage
Methods and devices for culturing human pluripotent stem cells to produce cells of the pancreatic lineage are disclosed. The methods include steps of culturing the stem cells under conditions that ind...
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Jon Odorico, Xiaofang Xu | P110310US02
Technology
Generating Arterial Endothelial Cell Populations
Methods for generating human arterial endothelial cells under defined conditions in the absence of insulin are described.
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James Thomson, Jue Zhang | P150123US02
Technology
Anti-Inflammatory Macrophages And Uses Thereof
The invention relates to a purified, novel anti-inflammatory population of macrophage and methods of making and using such macrophage.
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Peiman Hematti, Jaehyup Kim | P09357US02
Technology
Substantially Pure Human Retinal Progenitor, Forebrain Progenitor, And Retinal Pigment Epithelium Cell Cultures And Methods Of Making The Same
Methods for producing substantially pure cultures of human neural retinal progenitor cells, forebrain progenitor cells, and retinal pigment epithelial cells are disclosed. In addition, the successful ...
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David Gamm, Jason Meyer | P09273US02
Technology
Controlling The Potential Of Primate Neural Stem Cells By Regulating Pax6
A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
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Su-Chun Zhang, Xiaoqing Zhang | P09295US03
Technology
Cardiac Differentiation Of Human Pluripotent Stem Cells Under Defined Conditions Using Matrix Overlay Methods
Methods for culturing the pluripotent stem cells to undergo epithelial-to-mesenchymal transition and for generating high-yield, high-purity cardiomyocyte cultures from pluripotent stem cells are descr...
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Timothy Kamp, Jianhua Zhang, Samira Azarin, Sean Palecek, Xiaojun Lian | P100142US02
Technology
Method For The Induction Of Arterial-Type Of Hemogenic Endothelium From Hpscs
This invention discloses a method for the induction of arterial-type of hemogenic endothelium.
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Igor Slukvin, Gene Uenishi | P170127US02
Technology
Xeno-Free Generation Of Tissue-Specific Progenitor Cells
The invention relates to purified, tissue-specific progenitors, methods of making and using such tissue-specific progenitors.
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Peiman Hematti, Jaehyup Kim | P100234US02
Technology
Simplified Basic Media For Human Pluripotent Cell Culture
Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS c...
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James Thomson, Guokai Chen | P100242US02
Technology
Directed Differentiation Of Primate Pluripotent Stem Cells Into Functional Basal Forebrain Cholinergic Neurons (Bfcns) And Medium Spiny Gabaergic Projection Neurons
Methods of efficiently converting primate pluripotent stem cells to GABA neurons or cholinergic neurons, as well as applications thereof, are disclosed.
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Su-Chun Zhang, Yan Liu, Lixiang Ma | P100266US02
Technology
Vitronectin-Derived Cell Culture Substrate And Uses Thereof
Vitronectin-derived cell culture substrates and methods of using the same for culturing pluripotent stem cells are presented.
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James Thomson, Guokai Chen, Zhonggang Hou | P110176US02
Technology
Generation Of Cardiomyocytes From Human Pluripotent Stem Cells
Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/β-catenin signaling is first activated in pluripotent cells, e.g.,...
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Sean Palecek, Timothy Kamp, Xiaojun Lian | P110259US02
Technology
Method Of Deriving Mature Hepatocytes From Human Embryonic Stem Cells
A method for producing mature hepatocytes having functional hepatic enzyme activity from human pluripotent cells is disclosed. The method includes the step of transferring an external vector that incl...
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James Thomson, Srikumar Sengupta | P120102US04