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29 Results for 'Protein interactions & function'
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Technology
UW-Madison researchers have developed a titin DNA construct (a ‘titin minigene plasmid’) that is useful for identifying agents that modulate the titin size reduction that correlates with a...
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Wei Guo, Yanghai Zhang | P230097US01
Technology
SARS-CoV-2 Polymerase Production
Coronaviruses are a group of RNA viruses that can cause disease. Some, such as the common cold, can cause mild disease, while others, such as COVID-19, can be lethal. An unusual characteristic of coro...
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Robert Kirchdoerfer | P210033US01
Technology
Immunoaffinity Chromatography Using Epitope Tags To Polyol-responsive Monoclonal Antibodies
Disclosed is a method of isolating, purifying, or concentrating a target compound. The method includes the steps of onjugating the target compound to an epitope for a polyol-responsive monoclonal anti...
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Richard Burgess, Nancy Thompson, Sarah Duellman | P04290US
Technology
Electronically Activated Strained Alkynes
R1 and R2 are hydrogen or C1 to C12 linear or branched alkyl; R3 is hydrogen, C1 to C12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R4 is ab...
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Jennifer Schomaker, Eileen Burke | P170043US02
Technology
Electronically Activated Strained Alkynes
Compounds of Formula I: [Image Omitted] wherein: R1 and R1′ are independently selected from hydrogen, halogen, C1-to-C12 linear or branched hydroxyalkyl, C1-to-C12 linear or branched halo-alkyl, ...
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Jennifer Schomaker, Eileen Burke | P170043US03
Technology
Methods And Systems For Transmission And Detection Of Free Radicals
The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from...
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J. Leon Shohet, Michael Sussman, Faraz Choudhury, Benjamin Minkoff, Grzegorz Sabat, Joshua Blatz | P170004US02
Technology
Reagents for Bioreversible Protein Esterification
Chemoselective transformations are of key importance in modern chemical biology. Protein esterification can, for example, be employed for labeling, enhanced cellular uptake and other useful protein mo...
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Ronald Raines, Kalie Mix | P150262US03
Technology
Enhancing Cell Penetration to Improve Drug Delivery
The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Ronald Raines, Kristen Andersen | P150031US02
Technology
Monomeric Fluorescent Protein-Ligand Complexes with Strong Fluorescence in the Far-Red Region
Fluorescent proteins can be found today in most molecular biology laboratories. Since the discovery of Green Fluorescent Protein (GFP) in the early 1960s, fluorescent molecules have revolutionized man...
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Wayne Schaefer, Ramaswamy Subramanian, Swagatha Ghosh | T150029WO01
Technology
Fluorescent Ligand Complexes with Strong Fluorescence in the Far-Red Region for Tissue and Cell Labeling
Biomarker engineering and development has evolved to answer infinitely complex biological questions and the discovery of novel molecules could provide additional tools for biotechnology. Fluorescent r...
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Wayne Schaefer, Ramaswamy Subramanian, Daniel Ferraro, Chi Yu, David Gibson, Swagatha Ghosh, P. Sai Sudha | T100009US02
Technology
New Disulfide-Bond Reducing Agent
Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
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Ronald Raines, John Lukesh | P140284US01
Technology
Predicting Protein Hot Spot Residues
Most biological processes involve multiple proteins interacting with each other. While the principles governing protein-protein interactions are not fully understood, it is known that a small subset o...
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Julie Mitchell, Xiaolei Zhu, Steven Darnell | P140357US01
Technology
Improved Ref Nuclease for Site-Specific DNA Cleavage
Restriction enzymes are commonly used to cleave double-stranded DNA. These enzymes bind to specific sequences of DNA (the ‘restriction site’) and cleave the DNA either at the recognition site or a...
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Michael Cox, Angela Gruber, Tayla Olsen | P130114US02
Technology
New Amphiphiles for Manipulating Membrane Proteins
Membrane proteins perform many crucial functions in vivo but are difficult to manipulate and study because they are not soluble in simple aqueous buffers. Solubilizing membrane proteins for physical c...
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Samuel Gellman, Pil Seok Chae | P09028US02
Technology
Improved Disulfide-Bond Reducing Agents
Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
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Ronald Raines, John Lukesh | P110330US02
Technology
New Amphiphiles for Manipulating Integral Membrane Proteins
Integral membrane proteins are crucial cellular components, helping to transfer material and signals through the cytoplasm or between different cell compartments. Analyzing the structures and function...
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Samuel Gellman, Pil Seok Chae, Soren Rasmussen, Brian Kobilka | P110170US02
Technology
Solubilizing and Characterizing Membrane Proteins Using Tandem Facial Amphiphiles
Membrane proteins play crucial roles in biology but are difficult to handle and analyze because of their physical properties. The structures of these proteins display extensive nonpolar surfaces, whic...
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Samuel Gellman, Pil Seok Chae | P110057US02
Technology
Controlling and Predicting the Stability of a Protein Against Degradation by Proteases
The pathogen Mycobacterium tuberculosis causes tuberculosis, one of the world’s deadliest diseases. Because the desaturase DesA3 is essential for survival of M. tuberculosis, this enzyme i...
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Brian Fox, Yong Chang, Craig Bingman, Gary Wesenberg | P08214US
Technology
Device That Rapidly Detects and Characterizes Interactions Between a Drug and Potential Protein Target
Identification and characterization of promising target molecules often presents a bottleneck in the search for new drugs. A variety of high throughput methods for probing protein interactions have em...
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Martin Zanni, John Wright, Eric Fulmer | P04405US
Technology
Modified Strains PJ69-7A and PJ69-7B for the Yeast Two-Hybrid System
The yeast two-hybrid system is a powerful technique used to detect protein-protein interactions. The technique has been used to establish physical interactions between genetically identified proteins,...
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Philip James | P00227US
Technology
New Tools for Solubilizing, Isolating and Characterizing Membrane Proteins
Membrane proteins perform many crucial functions in vivo. Physical characterization of these proteins, including the determination of three-dimensional crystal structures, could improve fundamen...
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Samuel Gellman, Pil Seok Chae, Brian Kobilka, Soren Rasmussen | P09037US02
Technology
Strain and Vector for Use with the Three Hybrid System
Three hybrid screens are used to detect RNA-protein interactions. A problem with three hybrid screens has been high background due to some cDNAs binding and activating transcription in the absen...
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Marvin Wickens, Beilin Zhang | P97099US
Technology
Method and Device for Measuring Electrical Conductance of Membranes with a Radio Frequency Probe
Biological membranes, such as cell membranes, are intrinsically impermeable to ions and polar molecules. Thus, transport of ions through biological membranes requires special channel or pump proteins ...
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Daniel van der Weide | P01413US
Technology
Heterogeneous Protein Foldamers Containing Alpha, Beta and Gamma Amino Acids
Foldamers are synthetic protein oligomers with discrete and predictable folding properties akin to those of natural proteins. They provide molecular tools to investigate large-molecule interactions su...
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Samuel Gellman, Ahlke Hayen, Margaret Schmitt, Felix Ngassa | P02125US
Technology
Microfluidics Platform and Method That Mimic the Cellular Environment
Most biochemical interactions are studied in solutions containing dilute concentrations of molecules. However, the complexity of the cellular environment makes it difficult to compare the results of s...
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David Beebe, Jaisree Moorthy, Richard Burgess | P04153US