Wisconsin Alumni Research Foundation

Technology

Common Variants of the Sodium Channel Alpha Subunits

The SCN5A gene encodes a human cardiac sodium (Na+) channel alpha subunit that carries the inward Na+ current in the heart. Three distinct polymorphic SCN5A clones, hH1, hH1a and hH1b, have been isola...
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Jonathan Makielski, Bin Ye, Michael Ackerman | P02284US

Technology

HERG CDNA with Native PolyA Tail

The human ERG gene encodes a potassium channel that is expressed in the heart. Mutations in the HERG channel are a common cause of long QT syndrome, a disorder associated with delayed cardiac repolari...
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Gail Robertson, Eugenia Jones, Blake Anson | P05401US

Technology

Stable Cell Lines Expressing hERG1a and 1b

Cardiac IKr channels are targets associated with inherited and acquired long QT syndrome (LQTS), a disorder that can lead to ventricular arrhythmias. Previously, IKr channels were thought to be compos...
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Gail Robertson, Eugenia Jones, Jinling Wang | P03380US

Technology

Human Heart Sodium Channel Beta1 Subunit (SCNB1)

The human heart sodium channel beta1 subunit (SCNB1) is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel. In addition, SCNB1 is...
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Jonathan Makielski, Bin Ye | P03207US

Technology

HERG-1 Transfected HEK 293 Cell Line B

Re-polarization of the cardiac action potential, which plays a critical role in maintaining normal cardiac rhythm, occurs mainly due to the action of potassium ion (K+) currents in the heart. The most...
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Craig January, Zhengfeng Zhou, Qiuming Gong, Gail Robertson, Blake Anson, Matthew Trudeau, Corey Anderson | P04289US

Technology

Cell Line Stably Expressing KvLQT1 and minK

One of the key potassium channels in the heart is formed by the co-assembly of protein products from the KvLQT1 (KCNQ1) and minK (KCNE1) genes, which produce the slowly activating delayed rectifier po...
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Craig January, Sridharan Rajamani, Corey Anderson | P03073US

WARF