The human heart sodium channel beta1 subunit is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel.
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Biological membranes, such as cell membranes, are intrinsically impermeable to ions and polar molecules. Thus, transport of ions through biological membranes requires special channel or pump proteins ...
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The liver detoxifies many of the drugs and toxins in blood, which poses a problem in drug development and testing because drugs are rapidly cleared from the system. In the mammalian fetus, the liver i...
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The human ERG gene encodes a potassium channel that is expressed in the heart. Mutations in the HERG channel are a common cause of long QT syndrome, a disorder associated with delayed cardiac repolari...
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Cardiac IKr channels are targets associated with inherited and acquired long QT syndrome (LQTS), a disorder that can lead to ventricular arrhythmias. Previously, IKr channels were thought to be compos...
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The human heart sodium channel beta1 subunit (SCNB1) is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel. In addition, SCNB1 is...
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The human either-a-go-go related gene (HERG1 or KCNH2) potassium channel is critical to maintaining normal cardiac rhythm. Because unintended block of HERG channel activity by drugs can cause long QT ...
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Re-polarization of the cardiac action potential, which plays a critical role in maintaining normal cardiac rhythm, occurs mainly due to the action of potassium ion (K+) currents in the heart. The most...
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Current methods for isolating and culturing primary (stem/progenitor) cells remain unsatisfactory because most primary cells die when transferred to culture, and the remaining cells usually develop mu...
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One of the key potassium channels in the heart is formed by the co-assembly of protein products from the KvLQT1 (KCNQ1) and minK (KCNE1) genes, which produce the slowly activating delayed rectifier po...
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A cell membrane is made up of lipid bilayers that include ion channels for controlling the flow of ions into and out of the cell. Certain ion channels open in response to signaling molecules, includin...
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The antibiotic vancomycin targets the peptidoglycan-containing bacterial cell wall. Inducible resistance to vancomycin and other glycopeptide antibiotics is becoming a serious health problem, necessit...
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