Wisconsin Alumni Research Foundation

Technology

Reagents for Bioreversible Protein Esterification

Chemoselective transformations are of key importance in modern chemical biology. Protein esterification can, for example, be employed for labeling, enhanced cellular uptake and other useful protein mo...
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Ronald Raines, Kalie Mix | P150262US03

Technology

Enhancing Cell Penetration to Improve Drug Delivery

The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Ronald Raines, Kristen Andersen | P150031US02

Technology

New Disulfide-Bond Reducing Agent

Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
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Ronald Raines, John Lukesh | P140284US01

Technology

Predicting Protein Hot Spot Residues

Most biological processes involve multiple proteins interacting with each other. While the principles governing protein-protein interactions are not fully understood, it is known that a small subset o...
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Julie Mitchell, Xiaolei Zhu, Steven Darnell | P140357US01

Technology

Improved Ref Nuclease for Site-Specific DNA Cleavage

Restriction enzymes are commonly used to cleave double-stranded DNA. These enzymes bind to specific sequences of DNA (the ‘restriction site’) and cleave the DNA either at the recognition site or a...
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Michael Cox, Angela Gruber, Tayla Olsen | P130114US02

Technology

New Amphiphiles for Manipulating Membrane Proteins

Membrane proteins perform many crucial functions in vivo but are difficult to manipulate and study because they are not soluble in simple aqueous buffers. Solubilizing membrane proteins for physical c...
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Samuel Gellman, Pil Seok Chae | P09028US02

Technology

Improved Disulfide-Bond Reducing Agents

Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
Learn More
Ronald Raines, John Lukesh | P110330US02

Technology

New Amphiphiles for Manipulating Integral Membrane Proteins

Integral membrane proteins are crucial cellular components, helping to transfer material and signals through the cytoplasm or between different cell compartments. Analyzing the structures and function...
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Samuel Gellman, Pil Seok Chae, Soren Rasmussen, Brian Kobilka | P110170US02

Technology

Microwave Dielectric Spectroscopy Method and Device

Proteins change conformation in solution for a variety of reasons, including events such as ligand binding. Most researchers use simple and readily available optical means to measure protein conformat...
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Daniel van der Weide, Kimberly Taylor | P02102US

Technology

Multidimensional Spectrometer

Over the last eight years, academic researchers have been developing a new set of spectroscopic techniques that are multidimensional versions of visible and infrared spectroscopies, such as two-dimens...
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Martin Zanni, Niels Damrauer | P07420US

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