Technologies
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WARF: P150382US01

All-Glass Optical Microresonator for Single Molecule Spectroscopy and More


INVENTORS -

Randall Goldsmith, Kassandra Knapper, Kevin Heylman

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing an improved optical microresonator platform with superior biocompatibility and performance.
OVERVIEWLabel-free sensing methods could enable detection and characterization of chemical species at the single molecule level without the aid of probes or modifications to the target of interest. Such capability would have powerful implications in medical diagnostics, toxicology and chemical quantification.

Whispering gallery mode (WGM) optical microresonators have been shown to be a highly effective platform for label-free sensing, reaching the single protein and single nucleotide level, and enabling label-free imaging of non-emissive particles. Of all the different shapes of WGM microresonators, microtoroidal resonators has shown the highest levels of sensitivity, including reaching the single molecule limit. This success derives from two main properties: high quality (Q) factor and low mode volume (V). In addition, microtoroidal resonators have the advantage of on-chip fabrication, a critical requirement for large-scale production and reduced complexity.

UW–Madison researchers recently developed ultrahigh-Q factor microtoroidal resonators useful in spectroscopy and optical processing (see WARF reference numbers P140153US01 and P140153US03). Their glass-on-silicon design resulted in many improvements, but silicon is known to disrupt some biological processes and can cause unwanted background absorption, limiting its utility. They continue to seek improvements in design and performance, and have now found a novel way to address this limitation.
THE INVENTIONBuilding on their previous work, the researchers have developed all-glass microtoroidal resonators with improved sensitivity (i.e., superior Q/V ratio). Unlike their SiO2 on Si counterparts, the new resonators can be made chip scale – a significant advantage. Moreover, the use of glass in place of silicon makes the platform more desirable for applications including label-free sensing due to optical transparency in the visible region. Additionally, glass is a robust, chemically inert material and more biocompatible than silicon.

The new fabrication method follows the same general scheme as the previously developed oxide-on-silicon toroids, but the materials are inverted. This results in a silicon toroid atop an oxide pillar, followed by thermal oxidation to form an all-glass structure in the final step.
APPLICATIONS
  • Improved optical microresonator platforms for label-free sensing, single particle/molecule microscopy and spectroscopy, photonics technologies (optical processing, filtering, signaling, etc.), microfluidics and more
KEY BENEFITS
  • Can be made chip scale
  • Superior biocompatibility, versatility and performance
  • Improved Q/V ratio
  • Addresses design and analysis challenges of silicon
  • Fabrication methods are fully scalable, high throughput and uniform.
STAGE OF DEVELOPMENTThe new methods have been used to fabricate glass-on-glass, high-Q factor microtoroidal resonators.
Contact Information
For current licensing status, please contact Mark Staudt at mstaudt@warf.org or 608-960-9845.
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Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.