WARF: P06068US

Glutamate 2,3-Aminomutases for Industrial Production of 3-Hydroxyproprionate


Perry Frey, Frank Ruzicka

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing the gene that encodes the enzyme glutamate 2,3-aminomutase.
OVERVIEWBeta amino acids, which are naturally produced from alpha amino acids, are crucial components of many pharmacologically active compounds. They are also useful precursors for preparing various industrial chemicals, including 3-hydroxyproprionate (3HP), a key intermediate in the synthesis of biodegradable plastics from biomass. Although UW-Madison researchers previously discovered an enzyme, lysine 2,3-aminomutase, which catalyzes the conversion of lysine and other alpha amino acids to their corresponding beta amino acid, no enzyme that specifically possesses glutamate 2,3-aminomutase activity has been reported.
THE INVENTIONThe UW-Madison reseachers have now identified, isolated and characterized the gene that encodes the enzyme glutamate 2,3-aminomutase. Glutamate 2,3-aminomutase catalyzes the conversion of alpha glutamic acid to beta glutamic acid. This gene was isolated from the bacterium Clostridium difficile.
  • Production of 3HP
  • Enables the production of beta glutamate from recombinant host cells
  • May be used to develop a simplified and inexpensive procedure for the large scale, in vitro synthesis of 3HP
  • Useful to identify other glutamate 2,3-aminomutases
Contact Information
For current licensing status, please contact Jennifer Gottwald at or 608-960-9854.
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