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WARF: P03206US

  • Assigned to WARF as biological material.

Cell Line Stably Expressing the Human Heart Sodium Channel Beta1 Subunit


INVENTORS -

Jonathan Makielski, Bin Ye, Carmen Valdivia

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in a stably transfected cell line expressing the beta1 subunit of the human heart sodium channel.
OVERVIEWThe human heart sodium channel beta1 subunit is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel.
THE INVENTIONUW-Madison researchers have developed a stably transfected cell line expressing the beta1 subunit of the human heart sodium channel. The beta1 subunit was first cloned in the early 1990s. The researchers have now re-cloned this subunit and created a cell line that permanently expresses it.
APPLICATIONS
  • Drug testing and screening
KEY BENEFITS
  • Allows electrophysiological and pharmacological studies free from interference of other ion channels
  • Only an alpha subunit needs to be transiently transfected into this cell line to conduct experiments with the combined subunits, saving the trouble and expense of co-transfection with both subunits
ADDITIONAL INFORMATION
For More Information About the Inventors
Contact Information
For current licensing status, please contact Jennifer Gottwald at jennifer@warf.org or 608-960-9854.
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