Technologies
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WARF: P01258US

Differentiation and Purification of Neural Precursors from Human Embryonic Stem Cells


INVENTORS -

Su-Chun Zhang, James Thomson, Ian Duncan

The Wisconsin Alumni Research Foundation is seeking commercial partners interested in developing a simple and efficient method of differentiating human embryonic stem cells into neural precursor cells.
OVERVIEWHuman embryonic stem (hES) cells have the potential to provide a source of specific cell types for research and ultimately, for therapeutic transplantation into humans.
THE INVENTIONUW-Madison researchers have developed a simple and efficient method of differentiating human embryonic stem cells into neural precursor cells for pharmaceutical screening and potential transplant therapy. This system is easily standardized. First, hES cells are aggregated into embryoid bodies. Next, the embryoid bodies are treated with fibroblast growth factors to induce the cells’ development into a relatively pure culture of neural precursor cells. The resulting neural precursor cells have been shown to differentiate into neurons and glia, both in vitro and after transplantation into neonatal mouse brains.
APPLICATIONS
  • Isolating a population of neural precursors
  • May lead to novel treatments for nervous system damage, including damage resulting from stroke or spinal cord injuries
  • Pharmaceutical and toxicological screening of a compound’s effect on neuronal development and function
KEY BENEFITS
  • Allows efficient differentiation of hES cells into transplantable neural precursor cells in a standard culture system
Contact Information
For current licensing status, please contact Andy DeTienne at adetienne@warf.org or 608-960-9857.
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Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.