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WARF: P03207US

  • Assigned to WARF as biological material.

Human Heart Sodium Channel Beta1 Subunit (SCNB1)


INVENTORS -

Jonathan Makielski, Bin Ye

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a cell line that stably expresses the beta1 subunit of the human heart sodium channel.
OVERVIEWThe human heart sodium channel beta1 subunit (SCNB1) is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel. In addition, SCNB1 is thought to be a cell adhesion molecule and may have multiple effects on other proteins.
THE INVENTIONThe beta1 subunit of the human heart sodium channel is now available as a biomaterial through WARF. SCNB1 was first cloned in the early 1990s. UW-Madison researchers have now re-cloned this subunit and created a cell line that stably expresses it.
APPLICATIONS
  • Drug testing and screening
  • Determining which molecules interact with SCNB1
KEY BENEFITS
  • May be co-expressed with alpha subunits of the sodium channel to more faithfully capture normal sodium channel function for electrophysiological and pharmacological studies.
ADDITIONAL INFORMATION
For More Information About the Inventors
Contact Information
For current licensing status, please contact Jennifer Gottwald at jennifer@warf.org or 608-960-9854.
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