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WARF: P00331US

  • Assigned to WARF as biological material.

Transgenic Mouse for Testing Chemotherapeutic Agents


INVENTORS -

Mary Ellen Perry, Susan Mendrysa

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in transgenic mice that are conditional knockouts for mdm2.
OVERVIEWThe gene mdm2 is a negative regulator of p53, which plays a key role in apoptosis and is important in chemotherapy. Mice with knockout mutations in mdm2 would be useful in studying this gene; however, mdm2 is also essential for embryonic development.
THE INVENTIONUW-Madison researchers have developed transgenic mice that are conditional knockouts for mdm2. In these mice, exons 7-9 of the mdm2 gene are flanked with a particular sequence. When exposed to a specific recombinase, these exons should be deleted, rendering the gene non-functional.
APPLICATIONS
  • Mice may be useful for testing chemotherapeutic agents.
  • Murine embryonic fibroblasts (MEFs) from the mice may also be useful for testing chemotherapeutic agents.
  • MEFs could be used as positive controls in assays to screen for compounds that interfere with the mdm2/p53 interaction.
KEY BENEFITS
  • Knockout mutations can be tissue specific.
Contact Information
For current licensing status, please contact Jennifer Gottwald at jennifer@warf.org or 608-960-9854.
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