Food & Supplements : Nutraceuticals

Food & Supplements Portfolios


Preen Oil: The Nutritional Approach to Chronic Inflammation

UW–Madison researchers have developed methods of using preen oil as a food supplement to treat chronic inflammation in human and non-human animals, birds and fish.

Preen oil may be given orally as a pharmaceutical composition, added to human food products or included in animal, bird or fish food. The fatty acids in the oil accumulate in tissues where they inhibit the pro-inflammatory cytokines IL-1 and IL-6 and reduce chronic inflammation, including chronic joint inflammation associated with rheumatoid arthritis and other diseases.

Tannins Boost Gastrointestinal Immunity

UW–Madison researchers have developed tannin-based formulations to counteract or prevent the gastrointestinal problems associated with parenteral/enteral feeding. The researchers discovered that various types of tannins, including proanthocyanidins and hydrolysable tannins, promote mucosal barrier strength and immunity.

The formulations can take solid or liquid form, and may include other nutrients like sugars, amino acids, lipids and vitamins.

GMP Protein Burns Fat, Boosts Bone Strength in Women

UW–Madison researchers have developed dietary approach to increase bone mineralization and fat metabolism in female humans and animals using GMP. The peptide can be isolated from whey using standard methods and administered in an effective amount as a food product, nutraceutical or dietary supplement.

Making Large Quantities of Health-Promoting Thiosulfinates

UW–Madison researchers have developed a simple and quick way of making large amounts of thiosulfinates and desirable conjugates.  They heated onions to inactive the enzymes, particularly LF synthase.  The precursor sulfoxide compounds in the heated onion, which were not destroyed by this process, were added to a small portion of macerated garlic.  The garlic extracts were washed to remove the native garlic organosulfur compounds, leaving a mixture of garlic enzymes and sulfoxide precursors from onions.  This mixture produces thiosulfinates, rather than LF, from the onion.  The thiosulfinates then can be extracted from the garlic-onion mixture.

This method results in high yields of thiosulfinates with high purity.  Traditional organic synthesis approaches would require chromatography purification and the use of toxic and dangerous chemicals to achieve such high yields and purity.  The thiosulfinate mixture then can be combined with thiols in water to easily yield mixed disulfide conjugates, which are odorless and maintain biological activities of the thiosulfinates.

Conjugated Nonadecadienoic Acid (CNA) Reduces Body Fat and Inhibits LPL Activity

UW-Madison researchers have developed a method of using conjugated nonadecadienoic acid (CNA) to inhibit LPL activity in humans or other animals. CNA is a 19 carbon, free fatty acid with a pair of conjugated double bonds. Its biological effects on the metabolism of body fat are similar to those of CLA.

To inhibit LPL activity, an agent containing CNA and at least one derivative of CNA is administered to an animal. In addition to controlling body fat in animals, CNA also acts to inhibit cyclooxygenase activity and platelet aggregation.

Fractionation of Whey Proteins by Complex Formation

UW-Madison researchers have developed an efficient and cost-effective method of separating whey proteins from solutions of whey protein concentrate by complexing them with polysaccharides. The process yields at least a 95 percent pure alpha-lactalbumin fraction and a 90 percent pure beta-lactoglobulin fraction.