Technologies

Explore WARF Inventions and Patents

WARF Technologies

WARF’s portfolio of more than 1,900 technologies covers a wide range of categories, including analytical instrumentation, pharmaceuticals, food products, agriculture, research tools, medical devices, pluripotent stem cells, clean technology, information technology and semiconductors.

Information summaries, which describe each technology and its applications, benefits, inventors and patent status, can be downloaded, printed and shared by clicking on the technology category links to the left on this page.


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New Inventions

Production of Medium-Chain Fatty Acids from Biorefinery Residue

UW–Madison researchers led by Profs. Daniel Noguera and Timothy Donohue have developed a method for converting unreacted chemical components in stillage to valuable medium-chain fatty acids, such as hexanoic and octanoic acids, using a mixture of microbes (e.g., anaerobic microbiome).

Operationally, a portion of the stillage stream is separated and fed to a bioreactor containing the mixture of microbes, which transforms a fraction of the stillage to MCFAs. The other fraction of the stillage can be sent on to the anaerobic digester to generate electricity (similar to existing biorefineries).
P170271US04

New Hormone Analogs for Treating Hypoparathyroidism

UW–Madison researchers have developed backbone-modified analogs of PTH(1-34). The analogs exhibit advantageous properties; they are biased toward Gs activation/cAMP production relative to β arrestin recruitment.

The analogs were generated via an unconventional strategy in which the backbone of a natural PTHR-1 agonist was altered, rather than the side-chain complement. More specifically, selected α-amino acid residues were systemically replaced with either β-amino acid residues or with unnatural D-stereoisomer α-amino acid residues.

The researchers have shown that backbone-modification can rapidly identify potent agonists with divergent receptor-state selectivity patterns relative to a prototype peptide.
P180053US02

Enzymatic Depolymerization of Lignin

UW–Madison researchers provide the first demonstration of an in vitro enzymatic system that can recycle NAD+ and GSH while releasing aromatic monomers from natural and engineered lignin oligomers, as well as model compounds composed of similar chemical building blocks. Nearly 10 percent of beta-ether units were cleaved when the system was tested on actual lignin samples.

The relevant enzymes include dehydrogenases, β-etherases and glutathione lyases. In an exemplary version, the system uses the known LigD, LigN, LigE and LigF enzymes from Sphingobium sp. strain SYK-6. A newly discovered heterodimeric β-aryl etherase (BaeA) can be used in addition to or instead of LigE.
P170274US02

Industrial Furnace With Flameless Combustion and Impingement Flow for Increased Efficiency, Reduced Emissions and Intensified Heat Transfer

An assistant professor of mechanical engineering technology and inventor from the University of Wisconsin Oshkosh has developed an industrial natural gas furnace and oven design that combines flameless combustion with high velocity impingement gas and air jets directed toward the product being heated. This novel combination has the potential to provide advantages over conventional technology that include higher energy efficiency, uniform temperature distribution, reduced NOx emissions, and intensified convection heat transfer. The design also has the potential to increase productivity by allowing more material to be processed within the same combustion area. This innovative system can be used for production of new furnaces as well as retrofitting existing installations.
T170023US01

Soybeans with Increased Resistance to Sclerotinia Stem Rot and Drought Tolerance

UW–Madison researchers have demonstrated that knocking down expression of a specific soybean respiratory burst oxidase homolog protein (GmRBOH-VI) leads to enhanced resistance to S. sclerotiorum and confers drought tolerance.

Using protein sequence similarity searches, the researchers identified seventeen GmRBOHs and studied their contribution to Sclerotinia disease development, drought tolerance and nodulation. Transcript analysis of all seventeen GmRBOHs revealed that out of the six identified groups, group VI (GmRBOH-VI) was specifically and drastically induced following S. sclerotiorum challenge. Virus-induced gene silencing of GMRBOH-VI resulted in enhanced resistance to the fungus and, coincidently, drought stress.

Based on these discoveries, the researchers have developed modified soybeans and production methods available for licensing.
P170294US03
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New Patents

Inhibiting Metadherin/SND1 Interaction to Treat Cancer

UW–Madison researchers and collaborators have developed a method to fight tumor growth and metastasis using novel peptides that inhibit interaction between MTDH and a protein called SND1.

The researchers found that MTDH-SND1 protein interaction is important for the expansion and function of prostate tumors as well as luminal and basal breast tumor initiating cells. Their work provides novel peptides that target this protein complex to help control tumor initiation, recurrence and metastasis by combating tumor initiating cells, with minimal impact on normal tissues.
P140424US02

Superabsorbent, Sustainable Aerogels

UW–Madison researchers have developed organic aerogels with excellent absorbent properties. They are made by combining a water soluble polymer and cellulose nanocrystals/nanofibers (CNFs) derived from biomass. The polymer, such as PVA (polyvinyl alcohol), is cross-linked to form a gel and then water is removed by freeze-drying. The surface of the aerogel is coated with an organosilane, making it highly water repellent and superoleophilic (‘oil loving’).
P140038US02

New Isogeometric Analysis Software for Seamless Integration of Design and Analysis

UW–Madison researchers have developed a new method for creating a CAD-compatible mesh during an isogeometric analysis process. Unlike existing techniques, the method creates meshes without any approximation and delivers optimal convergence rates.

In essence, the researchers have developed a smoothing step that prevents inconsistencies from being introduced into the meshing process as a geometric map of the object is being refined.
P150209US01
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