WARF: P04326US

Systems and Methods for the Cyclotron Production of Iodine-124


Jonathon Nye, Robert Nickles

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing an improved method for the cyclotron production of I-124.
OVERVIEWPosition emission tomography (PET) plays a vital role in the diagnosis of health and disease. The long-lived isotope iodine-124 (I-124; half-life 4.2 days) has many features that make it an attractive imaging agent for PET; however, commercial biomedical cyclotrons have not been able to produce large quantities of I-124.
THE INVENTIONUW-Madison researchers have developed an improved method for the cyclotron production of I-124 using an aluminum telluride (Al2Te3) target. The method involves producing I-124 from an isotopically enriched aluminum telluride target via the 124Te(p,n) or 124Te(d,2n) reaction. The I-124 formed during irradiation is sublimated from the target stock by dry distillation in a resistive furnace and then swept in a gas stream to a chilled quartz trap downstream. It may be delivered as a solid film on a quartz tube or extracted by scrubbing with a mild base for radio labeling.
  • Production of I-124 for PET
  • Enables the production of I-124 in commercially useful quantities
  • Improves trapping of I-124
  • Allows I-124 to be used in PET scans of molecular compounds that accumulate slowly in target cells in the human body
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For current licensing status, please contact Jeanine Burmania at or 608-960-9846.
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