Technologies
PDF


WARF: P130340US01

X-Ray Phase Contrast Imaging Using Standard Equipment


INVENTORS -

Guang-Hong Chen

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a method for generating X-ray phase contrast images using conventional X-ray imaging systems.
OVERVIEWPhase contrast imaging exploits differences in the refractive index of materials to differentiate and image them. Recently, X-ray phase contrast imaging has attracted a great deal of attention. In the process, an X-ray detector converts phase variations into intensity variations as the beams pass through a subject.

Compared to normal absorption X-ray imaging, phase contrast imaging provides higher contrast and makes it easier to see smaller details. However, a major disadvantage is the sophisticated equipment that is required (e.g., synchrotron, high resolution detectors, etc.). This has hampered widespread implementation.

To be more practical in a clinical setting, a new approach must not involve specialized equipment or increased dose exposure to patients.
THE INVENTIONA UW–Madison researcher has developed a method for generating X-ray phase contrast images from conventional X-ray attenuation data.

First, calibration factors are obtained using a phantom. The patient or object then is X-rayed to acquire attenuation data at two different energy levels. Images are reconstructed at the different energy levels to produce spatial maps. Based on the calibration factors and spatial maps, a phase contrast image can be produced.
APPLICATIONS
  • Phase contrast imaging software
  • Any dual-energy computed tomography (CT) system
  • Diagnostic CT, image-guided interventions and radiation therapy, tomosynthesis used in breast imaging, diagnosis of diseases like gout and arthritis
KEY BENEFITS
  • Practical in a clinical setting
  • Requires no specialized hardware or modifications
  • Can be implemented in currently available X-ray imaging systems
Contact Information
For current licensing status, please contact Jeanine Burmania at jeanine@warf.org or 608-960-9846.
The WARF Advantage

Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.