WARF: P110244US02

Correcting for Patient Motion with T1-Weighted PROPELLER MRI


Howard Rowley, Jean Brittain, James Holmes, Reed Busse, Ajeetkumar Gaddipati, Philip Beatty, Xiaoli Zhao, Zhiqiang Li

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a parallel imaging technique that enables clearer scans while maintaining the requirements for T1 tissue contrasting.
OVERVIEWA leading method for reducing motion blurring in medical imaging is called PROPELLER (Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction). It allows doctors to track and help correct for the movement of a patient during magnetic resonance imaging (MRI) scans. This technology can make clearer images with faster scanning and result times. It is especially useful for patients who move, like children and those with conditions such as Parkinson’s disease.

However, acquiring motion-corrected parallel images is challenging with T1-weighted FLAIR, a lesion-detecting MRI technique that removes the effects of fluid from images. This is because its short pulse sequence, or echo train length (ETL), limits the width of the blades that can be used with PROPELLER. Reconciling these issues is vital.
THE INVENTIONResearchers have developed a technique that enables motion-corrected images to be acquired with T1 FLAIR contrast by combining PROPELLER and parallel imaging with calibration data shared between blades.

Using data from a shared external calibration blade reduces the number of internal calibration lines needed and enables higher acceleration for each blade. Maintaining short ETL readouts, the high parallel imaging acceleration increases the effective blade width significantly to allow for motion correction.
  • Software package for PROPELLER
  • Combines motion correction with T1 FLAIR contrasting
  • Supports more accurate MRI images
  • Improves scans of moving or shaking patients, including children
  • Allows for effective blade width increase to 27
STAGE OF DEVELOPMENTThe method was validated using volunteers instructed to move their heads during imaging.
For More Information About the Inventors
  • Holmes et al. 2012. Improved Motion Correction Capabilities for Fast Spin Echo T(1) FLAIR Propeller Using Non-Cartesian External Calibration Data Driven Parallel Imaging. Magn Reson Med.
Tech Fields
Contact Information
For current licensing status, please contact Jeanine Burmania at or 608-960-9846.
The WARF Advantage

Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.