WARF: P06132US

Image Reconstruction Method for Cardiac Gated Magnetic Resonance Imaging


Charles Mistretta

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a new method for reconstructing cardiac gated magnetic resonance (MR) images.
OVERVIEWMagnetic resonance imaging (MRI) is a medical imaging technique that takes measurements, or “views,” of a subject’s nuclear magnetic resonance (NMR) to form images of internal structures.  Magnetic resonance angiography (MRA) uses the same magnetic resonance phenomenon to produce images of the human vasculature and heart.  MRA images can be enhanced by a contrast agent, but this method needs to be timed precisely to capture images during the short time when the agent is entering the vasculature.

When imaging certain arteries, the results are greatly affected by the beating of the heart.  Cardiac gating, which employs electrocardiography (ECG) to trigger acquisition of an image at a certain point in the heart’s cardiac cycle, is necessary to allow the same image to be taken throughout multiple cardiac phases.  Two-dimensional images have been acquired using this technique, but no existing method is fast enough to acquire a 3-D image or multiple 2-D images at each cardiac phase.
THE INVENTIONA UW-Madison researcher has developed a new method for reconstructing cardiac gated MR images and specifically for improving the quality of highly undersampled cardiac phase images.  A series of views for one image from a specific cardiac phase are combined into a composite image.  Then a highly constrained backprojection method, using the composite image, allows for the reconstruction of 2-D and 3-D images for each phase.  A highly sampled composite image also can be constructed from multiple undersampled images from a certain cardiac phase to increase the signal-to-noise ratio of the final images.
  • Image reconstruction for cardiac gated MRI
  • Increases 2-D image quality for cardiac gated MRI
  • Produces good quality 3-D images for cardiac gated MRI
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For current licensing status, please contact Jeanine Burmania at or 608-960-9846.
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