WARF: P02017US

Magnetic Resonance Angiography Using Floating Table Projection Imaging


Charles Mistretta

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing an improved technique for obtaining whole body MRA images as a patient is moved through the FOV of an MRI scanner.
OVERVIEWMagnetic resonance angiography (MRA) uses the magnetic resonance phenomenon in conjunction with a signal-enhancing contrast agent to provide images of blood vessels. MRA is a valuable, non-invasive screening tool for cardiovascular diseases; however, the small field of view (FOV) in MRA limits the volume of blood vessels that can be imaged during a scan. When diagnosis requires imaging of a large volume (such as in the lower extremities of the body) multiple scans must be performed, each requiring lengthy and expensive patient repositioning, preparatory scans and re-injection of contrast agent.
THE INVENTIONA UW-Madison researcher has developed an improved technique for obtaining whole body MRA images as a patient is moved through the FOV of an MRI scanner. As the patient travels through the scanner on a table moving at approximately the same speed as a bolus of contrast agent moving through the patient’s vasculature, image data are continuously acquired for each sub-region of the patient’s body. To offset the effects of table motion, each data set is phase corrected to a reference position. These data are then used to construct an image of each sub-region. To speed image capture while maintaining image quality, the invention employs Mistretta’s Vastly Undersampled Imaging with Projections (VIPR) technique (see link below) to acquire image data.
  • MR imaging of blood vessels
  • Promises a whole-body imaging technique with the simplicity of CT, but with all the special contrast mechanisms available with MRI
  • By effectively combining data from a number of spatially-limited field of views (FOVs), could allow capture of whole-body MRI images using inexpensive, short-bore magnets
  • Makes use of projection reconstruction data acquisition, which provides time-resolved series of images with high spatial and temporal resolution (see below)
  • Eliminates need for the expensive and time-consuming patient and scanner re-adjustments required to acquire multiple FOVs during MRA
  • Acquires image data continuously as patient moves through scanner, allowing better timing of the scan to contrast agent movement than previous, “stop-and-go” whole-body MRI techniques
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Contact Information
For current licensing status, please contact Jeanine Burmania at or 608-960-9846.
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