WARF: P130041US01

Medical Imaging with Better Temporal Fidelity Can Streamline Stroke Care


Guang-Hong Chen, Jie Tang

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a method that removes blurring caused by low temporal resolution and enables increased sampling density for contrast dynamics.
OVERVIEWThe outcome of a stroke can hinge on the time spent on diagnosis and intervention. Perfusion imaging is a critical step in the process, wherein a patient is scanned to identify salvageable tissue. These perfusion studies can take hours to schedule and perform. Transporting patients between imaging and intervention suites is a race against time.

Health care could be streamlined if perfusion studies were performed with the same c-arm computed tomography (CT) system used for intervention. Two major challenges hinder this. First, these systems are too slow to accurately record ‘contrast dynamics,’ or factors that vary with time (such as an imaging agent injected in a subject). Also, the number of acquired time frames is too few to estimate perfusion information from time density curves.

Software that would enable the current hardware to perform perfusion imaging is highly desirable.
THE INVENTIONUW–Madison researchers have developed a method that increases temporal fidelity, sampling density and/or reduces noise of image frames obtained with a system such as CT, MRI or X-ray c-arm. After the images are acquired, a window function is selected and temporally deconvolves the image frames using a minimization technique. A temporal sampling density also may be selected and used in the temporal deconvolution.
  • Perfusion imaging software
  • Better imaging with higher temporal fidelity
  • Clearer depiction of time-varying image contrasts
  • Increased temporal sampling density and/or reduced temporal noise
  • No hardware modification
Contact Information
For current licensing status, please contact Jeanine Burmania at or 608-960-9846.
The WARF Advantage

Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.