WARF: P02108US

Time-Resolved, Computed Tomographic Angiography


Charles Mistretta

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a method to reduce streak artifacts in a time-resolved series of CT images.
OVERVIEWResearchers have recently achieved computed tomographic (CT) imaging of large volumes by using rotating gantries equipped with large-area, flat-panel detectors and have applied this technique to contrast-enhanced (CE) angiography. To get the best diagnostic image in CE angiography, a series of images must be quickly obtained during contrast agent injection; however, readout with flat-panel CT detectors is relatively slow. Thus, when this technique is used to rapidly capture images during angiography, only limited image data can be acquired during each rotation, resulting in angiographic images with streak artifacts.
THE INVENTIONA UW-Madison researcher has developed a means of reducing streak artifacts in a time-resolved series of computed tomographic images. It involves placing a patient in a CT scanner and performing an initial gantry rotation to obtain a pre-injection, mask image. Next, contrast agent is injected and a series of under-sampled images are acquired during sequential gantry rotations. Each rotation occurs at a slightly different angular orientation than the last, so that images acquired during each rotation interleave with each other. Images are then transformed into spatial frequency (k-space) data, and processed back into image data through a technique similar to that used in time-resolved, magnetic resonance VIPR (vastly under-sampled isotropic projection imaging – see WARF reference number P01008US). By sharing peripheral k-space data from interleaved, under-sampled images, this technique produces a time-resolved series of more fully-sampled, CT images with minimal streak artifacts.
  • Time-resolved CT images
  • Promises to allow application of modern, flat-panel detector technology to time-resolved contrast-enhanced CT angiography
  • Provides a large-volume, time-resolved series of CT images while minimizing streak artifacts
  • X-ray dose flexibility of CT should overcome signal-to-noise limitations of other angiographic imaging modalities, such as MRI.
  • Employs Mistretta’s Vastly Under-sampled Isotropic Projection Imaging (VIPR) technology, which offers rapid image capture without loss of resolution
  • Pre-injection mask allows subtraction of bone and other tissues from diagnostic images
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For current licensing status, please contact Jeanine Burmania at or 608-960-9846.
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