WARF: P110289US01

Ultra-High Frame Rate, Time-Resolved, 4-D MRA


Charles Mistretta

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a system and method for producing time-resolved, 3-D angiographic images.
OVERVIEWSince the introduction of angiography, there have been many attempts to develop techniques that provide diagnostic images of the vasculature while reducing invasiveness.

A technique called 4-D DSA (digital subtraction angiography) has been developed for generating detailed series of time-resolved, 3-D medical images of a subject with both high temporal resolution and excellent spatial resolution. This is done by imparting temporal information from a time series of 2-D images onto a still 3-D image.

However, acquiring both the 2-D and 3-D data sets may require multiple imaging subsystems, such as fluoroscopy and computed tomography (CT), which require the use of ionizing radiation. A new approach must be less expensive and complex, and avoid ionizing radiation.
THE INVENTIONA UW–Madison researcher has developed a system and method for producing time-resolved 3-D medical images of a subject from a time series of 2-D data sets and a time-independent 3-D volume of the subject.

The 2-D time series of images is obtained using MRI, and then combined with the time-independent 3-D volume to generate a set of time-dependent 3-D volume images of the subject at the frame rate of the acquired 2-D data sets. The system is able to reconstruct multiple sets of 2-D time series of images at different view angles. Reconstruction can be done using HYPR, a processing technique previously developed by the researcher.
  • Diagnostic magnetic resonance angiography (MRA)
  • Generates high-quality 3-D image volumes at high frame rates and without ionizing radiation
Contact Information
For current licensing status, please contact Jeanine Burmania at or 608-960-9846.
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Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.